PMID: 11905522Mar 22, 2002Paper

Changes in calcaneal trabecular bone structure assessed with high-resolution MR imaging in patients with kidney transplantation

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
T M LinkS Majumdar

Abstract

The purpose of this study was to use high-resolution magnetic resonance (HR-MR) imaging to analyze the trabecular bone structure of the calcaneus in patients before and after renal transplantation and to compare this technique with bone mineral density (BMD) in predicting therapy-induced bone loss and osteoporotic fracture status. HR-MR imaging (voxel size: 0.195 x 0.195 x 1 mm) was performed at 1.5 T with an axial and sagittal orientation in 48 patients after transplantation, 12 patients before renal transplantation and 20 healthy controls. Structure measures analogous to standard histomorphometry and fractal dimension were determined in these images. BMD measurements of the lumbar spine and the proximal femur were obtained in the healthy female controls and the patients. Vertebral and peripheral fracture status were determined in all patients. The structural measures app.BV/TV, Tb.Sp, Tb.Th and Tb.N showed significant differences between controls and patients (p<0.05) while fractal dimension showed no significant differences. Neither the structural measures nor BMD showed significant differences between patients before and after transplantation. Correlations between time after transplantation versus structural measures and BM...Continue Reading

Citations

Sep 13, 2002·NMR in Biomedicine
Feb 5, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mary B Leonard
Jul 12, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mary B Leonard
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Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·Felix W Wehrli
Jun 27, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A D LalayiannisR Shroff
Jan 6, 2021·Calcified Tissue International·Jordi BoverCarlos Gómez-Alonso

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