Changes in calcitonin release during sympathetic nerve degeneration after superior cervical ganglionectomy of rats

Neuroendocrinology
D P CardinaliR J Soto

Abstract

To assess the role of peripheral sympathetic nerves in the regulation of calcitonin release, rats subjected to superior cervical ganglionectomy (SCGx) 16-28 h earlier were used. The time periods selected allowed us to examine C cell response during the supraliminal release of sympathetic transmitter that accompanies anterograde degeneration of nerve varicosities as well as during the neural paralysis that ensues thereafter. At the time intervals examined, SCGx did not result in significant changes of basal serum calcitonin or Ca levels. The intraperitoneal administration of CaCl2 brought about an impending increase of serum Ca to the same extent in SCGx and sham-operated rats. A significant depression of calcitonin release was observed in rats killed around the time of nerve terminal degeneration (16-21 h post SCGx) but not about 10 h later. Additionally a delay to achieve a maximal calcitonin response was apparent during nerve degeneration. Injection of the alpha-adrenoceptor blocker phenoxybenzamine significantly increased basal calcitonin levels and restored the depressed calcitonin response to hypercalcemia seen in SCGx rats. Treatment with the beta-adrenoceptor-blocker propranolol counteracted phenoxybenzamine activity but...Continue Reading

Citations

Jan 1, 1988·Journal of Neural Transmission·M BarontiniD P Cardinali
Sep 1, 1986·Journal of the Autonomic Nervous System·H E RomeoD P Cardinali
Mar 1, 1988·Journal of the Autonomic Nervous System·J B GarcíaD P Cardinali
Jun 1, 1994·Journal of the Autonomic Nervous System·J E SternD P Cardinali
Sep 1, 1995·Journal of Neuroendocrinology·J E Stern, D P Cardinali

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