PMID: 8967890Nov 1, 1995Paper

Changes in calcium handling in atrophic heterotopically isotransplanted rat hearts

Basic Research in Cardiology
F KolarK Rakusan

Abstract

Atrophy of the rat heart induced by hemodynamic unloading after heterotopic transplantation is associated with impaired relaxation while systolic function remains normal when compared to the heart of the recipient animal. To identify possible underlying mechanisms for the above, we studied some aspects of membrane calcium handling using postextrasystolic potentiation of contractions in the isolated right ventricular papillary muscle and in the left ventricle of the Langendorff-perfused heart. We also compared the alterations of the unloaded heart with those of overloaded hypertrophic hearts of rats with suprarenal aortic constriction. In the atrophic heart the degree of potentiation after one extrasystole, considered to be proportional to the trans-sarcolemmal influx of Ca2+ during an action potential, was increased by 125% when compared with recipient hearts. The rate of decay of potentiation which reflects the fraction of activator Ca2+ recirculating in the cells via the sarcoplasmic reticulum, negatively correlated with the degree of potentiation, although its mean value was not significantly altered. In hypertrophic hearts the decay of potentiation was faster when compared with the hearts of sham-operated animals, indicatin...Continue Reading

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Citations

Jan 12, 2010·Annual Review of Medicine·Cesare M TerraccianoMagdi H Yacoub
Apr 11, 2000·Journal of Molecular and Cellular Cardiology·M RitterW H Barry
Oct 14, 2008·Journal of Molecular and Cellular Cardiology·Alexander P SchwoererAli El-Armouche
Jul 29, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Gopal K R SoppaCesare M N Terracciano
Aug 30, 2008·Journal of Molecular and Cellular Cardiology·Alexander Peter SchwoererHeimo Ehmke
Apr 21, 2007·Annals of the New York Academy of Sciences·Cesare M N TerraccianoMagdi H Yacoub
Jul 7, 2005·The Journal of Thoracic and Cardiovascular Surgery·Tomohiro MizunoRen-Ke Li
Dec 8, 2004·Journal of the American College of Cardiology·Tohru TakaseyaShigeaki Aoyagi
Aug 6, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Choon-Sik JhunJoshua P Cysyk

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