Changes in capillary shear stress in skeletal muscles exposed to long-term activity: role of nitric oxide

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Olga HudlickaAxel R Pries

Abstract

The purpose of this study was to establish whether suppression of angiogenesis by nitric oxide synthase (NOS) inhibition in skeletal muscles exposed to long-term activity can be explained by changes in capillary shear stress linked to the lack of nitric oxide production. Capillary shear stress was calculated from diameters (d) and red blood cell velocities (V(rbc)) measured at rest and after acute contractions in epi-illuminated extensor digitorum longus muscles of control rats and those in which ankle flexors had been stimulated via implanted electrodes (10 Hz, 8 h x day(-1)) for 2 or 7 days without and with inhibition of nitric oxide synthase activity by N(omega)-nitro-L-arginine (L-NNA, 3-4 mg x day(-1) in drinking water). Neither chronic electrical stimulation nor L-NNA treatment altered capillary diameters. Capillary V(rbc) and shear stress (SS) were doubled in muscles after 2 days stimulation (298 +/- 22 microm x s(-1) and 11.4 +/- 1.0 dyne x cm(-2), respectively, p < .005) compared to controls (148 +/- 18 microm x s(-1) and 5.6 +/- 0.8 dyne x cm(-2)) but normalized after 7 days (153 +/- 27 microm x s(-1) and 6.2 +/- 1.0 dyne x cm(-2)), when the capillary bed is known to be enlarged. L-NNA, which increased blood pressure ...Continue Reading

References

Apr 1, 1992·Physiological Reviews·O HudlickaS Egginton
Nov 1, 1995·Circulation Research·A R PriesP Gaehtgens
Dec 1, 1994·Journal of Applied Physiology·T W Balon, J L Nadler
Feb 1, 1996·The American Journal of Physiology·Y JiangJ A Rall
Nov 1, 1996·Journal of Applied Physiology·M D Frame, I H Sarelius
Jan 12, 2001·Physiological Reviews·J S Stamler, G Meissner
Jun 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ayelet Shay-SalitNitzan Resnick
Oct 10, 2002·American Journal of Physiology. Cell Physiology·Yingxiao WangShu Chien
Aug 6, 2003·American Journal of Physiology. Cell Physiology·Yong Chool Boo, Hanjoong Jo
Nov 6, 2003·Sports Medicine·Andrew MaioranaDaniel Green
Jan 9, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Robert Boushel
May 4, 2004·Biochemical and Biophysical Research Communications·Michael K JonesDolgor Baatar
Jul 16, 2004·American Journal of Physiology. Cell Physiology·Richard E WatersZhen Yan
Aug 31, 2004·Journal of Applied Physiology·Barry M PriorRonald L Terjung
Sep 18, 2004·The Journal of Physiology·Daniel J GreenRoger Taylor
Sep 28, 2004·Journal of Applied Physiology·R M McAllisterM H Laughlin
Mar 17, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Renate B Pilz, Kate E Broderick

❮ Previous
Next ❯

Citations

Mar 25, 2011·Medical & Biological Engineering & Computing·Xuewen ChenDov Jaron
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jonathan W Song, Lance L Munn
Nov 26, 2008·Cardiovascular Research·Axel R Pries, Timothy W Secomb
May 4, 2011·Acta Physiologica·B Styp-RekowskaV Djonov
Jul 1, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Matthew CocksAnton J M Wagenmakers
Jan 24, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Birgitte Hoier, Ylva Hellsten
Nov 21, 2012·Journal of Tissue Engineering and Regenerative Medicine·Yuchun LiuSwee-Hin Teoh
Sep 19, 2014·European Heart Journal·Brenda R KwakPaul C Evans
Nov 23, 2011·Biochemical Society Transactions·Stuart Egginton
Apr 28, 2016·Archivos de cardiología de México·Iván Rodríguez-NúñezMaría Javiera Saavedra
Nov 18, 2016·American Journal of Respiratory and Critical Care Medicine·Ru-Ting HuangYun Fang
May 4, 2018·Journal of Applied Physiology·Ida Torp AndersenJessica Pingel
May 11, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Katie HeskethMatthew Cocks
Nov 20, 2016·PloS One·Erin R MandelTara L Haas
Sep 13, 2020·Brain Structure & Function·Morgan E StevensonRodney A Swain
Nov 28, 2018·The Journal of Physiological Sciences : JPS·Tomohiro MatsumotoHidemi Fujino
Dec 6, 2006·Essays in Biochemistry·Anton J M WagenmakersPaul M Stewart
Apr 12, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Oliver BaumHans Hoppeler
Jun 6, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Flávio de Castro MagalhãesFabiano Trigueiro Amorim
Nov 13, 2020·Frontiers in Physiology·Ricardo SantamaríaAlicia G Arroyo
Nov 2, 2019·Journal of the Mechanical Behavior of Biomedical Materials·Qiuyun WangQianhong Wu
Nov 24, 2018·International Journal of Biological Macromolecules·Selvaraj VimalrajSuvro Chatterjee
Nov 27, 2021·Science Advances·John-Michael ArpinoJ Geoffrey Pickering

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.