Changes in CD23 expression of blood and skin in atopic eczema after Chinese herbal therapy

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
P BanerjeeM H Rustin

Abstract

Aberrant expression of CD23 (low affinity IgE receptor) on cells of the monocyte/macrophage series in peripheral blood and lesional skin of patients with atopic eczema has been demonstrated. It is not known whether this abnormality results from a fundamental systemic problem of the monocytes of these patients or reflects local changes to cell populations within the skin tissues. This study was designed to determine whether this aberrant expression was caused by local cutaneous influences on mature cells or fundamental changes in monocyte differentiation. The possible relationship between these aberrations and clinical severity was also investigated by repeating these immunopathological studies after a course of efficacious treatment with Chinese herbal therapy (CHT). Peripheral blood mononuclear cells were obtained from patients with atopic eczema before, and after 8 weeks of treatment. Efficacy of CHT was quantified on clinical grounds. Monocytes were isolated by adherence to plastic and cultured for up to 7 days. Samples were harvested at 2, 5 and 7 days of culture and cytospins prepared. Immunocytochemical staining to identify phenotypic subsets was performed on the monocytes at time 0 and on maturing cells from culture. Thi...Continue Reading

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Citations

May 25, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Guorang HuVal Gebski
Aug 27, 2011·Experimental Eye Research·Gregory H GrossmanStephanie A Hagstrom
Sep 2, 2017·Chinese Journal of Integrative Medicine·George ManMao-Qiang Man

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