PMID: 9425692May 1, 1997Paper

Changes in CD44 isoform expression during inflammatory skin disease

Clinical and Experimental Dermatology
A L HarrisF Wojnarowska

Abstract

The CD44 family of cell surface glycoproteins is widely expressed in epithelial, mesothelial and haemopoietic tissues and is thought to function primarily as adhesion molecules. The molecule has an intracellular, a transmembrane and an extracellular domain. The membrane proximal region of the extracellular domain is of variable structure depending on which of 10 variable exons are involved in coding for this region. Both in vitro stimulated T cells and cytokine stimulated keratinocytes are known to express certain isoforms. In this study we have investigated whether specific isoforms of the CD44 molecule are expressed on epithelial cells and lymphocytes in the course of two inflammatory skin diseases, namely lupus erythematosus and lichen planus. Monoclonal antibodies, specific to the epitopes of the CD44 molecule encoded by v3, v4/5, v6 and v8/9 variable exons and a pan CD44 marker, were used on 10 lupus and 8 lichen planus frozen skin samples and compared with normal skin from 9 different body sites. Results failed to show detectable levels of variant isoforms of CD44 on lymphocytes in either inflammatory skin disease, despite evidence of T cell activation. All CD44 variant isoforms were reduced on the keratinocytes in some s...Continue Reading

References

Feb 1, 1992·The Journal of Cell Biology·M CultyC B Underhill
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G R ScreatonJ I Bell
Dec 1, 1989·Immunology Today·B F HaynesS M Denning
Jan 1, 1994·The Journal of Cell Biology·C R MackayU Günthert
Aug 1, 1993·Immunology Today·P HerrlichH Ponta

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Citations

Feb 20, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·E NeppelbergA C Johannessen
Nov 26, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Maria SiponenSanna Pasonen-Seppänen

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