Sep 25, 1998

Changes in cell, matrix compartment, and fibrillar collagen volumes between growth-plate zones

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
K J NoonanJ A Buckwalter

Abstract

To define the contributions of changes in cell, matrix compartment, and fibrillar collagen volumes to longitudinal bone growth, we measured the differences in cell, pericellular/territorial matrix and interterritorial matrix volumes, and fibrillar collagen concentrations between the upper proliferative and lower hypertrophic zones of the proximal tibial physes of six miniature pigs. The mean numerical density of cells decreased from 110,000 cells/mm3 in the upper proliferative zone to 59,900 cells/mm3 in the lower hypertrophic zone. The mean cell volume increased nearly 5-fold (from 1,174 to 5,530 microm3), and the total matrix volume per cell increased 46% (from 8,040 to 11,760 microm3/cell) between the upper proliferative and lower hypertrophic zones. Both the pericellular/territorial matrix volume per cell and the interterritorial matrix volume per cell increased between the upper proliferative and lower hypertrophic zones; the pericellular/territorial matrix volume per cell increased 61% (from 4,580 to 7,390 microm3/cell), whereas the interterritorial matrix volume per cell increased 26% (from 3,460 to 4,370 microm3/cell). The total increase in mean cell volume of 4,356 microm3 exceeded the total increase in mean matrix vol...Continue Reading

  • References19
  • Citations37

References

  • References19
  • Citations37

Citations

Mentioned in this Paper

Hypertrophic Cardiomyopathy
Fibrillar Collagen
Extracellular Matrix
Hypertrophy
Chondrocyte
Skeletal System
Cell Enlargement
4',5'-bis(N, N-bis(carboxymethyl)aminomethyl)fluorescein acetoxymethyl ester
Fibrillar Collagen Location
Tetraiodofluorescein

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