Changes in cell phenotype during regeneration of junctional epithelium of human gingiva in vitro.

Journal of Periodontal Research
J SalonenB A Dale

Abstract

The relationship between cell attachment and the phenotype of the attached oral epithelial cells was studied by comparing junctional epithelium (JE) with a culture model for JE in which epithelial cells form an equivalent organization of tissues. Gingival explants were cultured on either a high or a low protein-binding membrane. The cut edge of epithelium and connective tissue was placed on the membrane; epithelial cells migrated to form a sheet of tissue between the explant and the membrane substratum. Cells which grew in contact with the high protein-binding membrane attached to the substratum and assumed a cuboidal shape. With time in culture these cells showed a decrease in reactivity with antibodies to psi-3 antigen (an antigen associated with epithelial migration) and an increase in reactivity with antibodies to cytokeratin 19 (a marker for JE). Cells grown on the low protein-binding membrane did not exhibit changes in shape or antigens. Because similar features were found in the JE in vivo, it was concluded that the junctional cells which are directly attached to the tooth (DAT cells) have a nonmigratory phenotype that develops as a response to the tooth surface. Because the cells are in contact with a metabolically iner...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Dec 1, 1986·Journal of Periodontology·D L Massoth, B A Dale
Sep 1, 1987·The Journal of Investigative Dermatology·J N Mansbridge, A M Knapp
Nov 1, 1987·Journal of Periodontal Research·B SteffensenC T Hanks
Sep 1, 1989·Journal of Periodontal Research·I C MackenzieU Mandel
May 1, 1987·Journal of Periodontal Research·I C Mackenzie
Jan 1, 1987·Annual Review of Cell Biology·G R Martin, R Timpl
Jan 1, 1987·Annals of the New York Academy of Sciences·H K KleinmanL Luckenbill-Edds
Aug 1, 1981·Journal of Periodontology·C A Squier
Nov 1, 1982·The Journal of Cell Biology·J Woodcock-MitchellT T Sun
Sep 1, 1982·Journal of Periodontal Research·V P Terranova, G R Martin
May 1, 1983·Journal of Periodontal Research·J Salonen, R Santti

❮ Previous
Next ❯

Citations

Jun 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·D Oda, E Watson
Jun 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·D OdaG Bourekis
Jan 12, 2007·Cell and Tissue Research·A Peyret-LacombeG Brunel
May 1, 1994·European Journal of Cancer. Part B, Oral Oncology·P R Morgan, L Su
Nov 24, 1999·Journal of Cataract and Refractive Surgery·R J LinnolaR P Happonen
Oct 1, 1991·Scandinavian Journal of Dental Research·J I Salonen, K U Paunio
Feb 20, 1998·European Journal of Oral Sciences·M Feghali-AssalyJ P Ouhayoun
Feb 1, 1997·Periodontology 2000·H E Schroeder, M A Listgarten
Aug 18, 2012·International Journal of Dentistry·M T PöllänenV-J Uitto
Nov 1, 1995·Journal of Periodontology·I C Mackenzie, M S Tonetti
May 14, 1998·Journal of Periodontology·L Blomlöf, S Lindskog
May 5, 2006·Journal of Periodontology·Jaana WillbergMarketta Hormia
May 6, 2008·Journal of Periodontology·Colin B WiebeHannu S Larjava
Apr 4, 2008·The Journal of Prosthetic Dentistry·Peter Schupbach, Roland Glauser
May 3, 2014·Scientific Reports·Sara Yajima-HimuroMatsuo Yamamoto
Nov 1, 2008·Journal of Periodontal Research·T KinumatsuM Shimono
Mar 27, 2003·Periodontology 2000·Marja T PöllänenVeli-Jukka Uitto
Jul 16, 2016·Archives of Oral Biology·Mazen K AlotaibiCharles F Shuler
Jan 2, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·R B Presland, B A Dale
Jul 5, 2002·Journal of Dental Research·V-J UittoU Saarialho-Kere
Dec 24, 2004·Journal of Dental Research·D D Bosshardt, N P Lang
Jul 16, 2014·Journal of Dental Research·M K AlotaibiC F Shuler
Sep 30, 2017·Advanced Healthcare Materials·Mohamed-Nur AbdallahFaleh Tamimi
Jun 22, 2005·Journal of Periodontal Research·Hiroki IshikawaMasaki Shimono
May 1, 1994·Journal of Periodontal Research·M Feghali-AssalyJ P Ouhayoun
Jan 1, 1994·Journal of Periodontal Research·J I Salonen
Jul 1, 1995·Journal of Periodontal Research·Y AbeI Kato
Sep 1, 1990·Journal of Periodontal Research·J P OuhayounN Forest
Nov 1, 1991·Journal of Periodontal Research·I C MackenzieE B Lane
Jul 1, 1991·Journal of Periodontal Research·J SalonenH Sage
Apr 1, 1997·Journal of Periodontal Research·M T PöllänenJ I Salonen
Feb 1, 2003·European Journal of Oral Sciences·Scott Thomas William McKeownChristopher Robert Irwin
Apr 3, 1998·Journal of Periodontal Research·M T PöllänenJ I Salonen
Jan 1, 1990·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·B A DaleA H Jones

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.