PMID: 1211308Oct 1, 1975Paper

Changes in cellular enzyme levels and the inhibition of selective release of lysosomal hydrolases from macrophages by indomethacin

Agents and Actions
C FinlayA C Allison

Abstract

Indomethacin increases the cellular levels of several lysosomal enzymes in cultures of mouse peritoneal macrophages exposed to the drug for periods of time ranging from one day to four weeks. This increase can be blocked by puromycin, an inhibitor of protein synthesis. Pretreatment of macrophages with indomethacin inhibits the selective release of lysosomal enzymes induced by a C-mucopolysaccharide peptidoglycan complex purified from the cell walls of Group A streptococci.

References

Jan 24, 1975·Science·L M WahlG R Martin
Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R M Pantalone, R C Page
Feb 15, 1974·Biochemical Pharmacology·M Kaliner, K F Austen
Oct 1, 1969·The Journal of Pathology·G B Ryan, W G Spector
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·L M WahlG R Martin
Nov 25, 1974·Prostaglandins·J Morley
May 1, 1972·Analytical Biochemistry·A J Barrett
Apr 1, 1973·The Journal of Experimental Medicine·J E Balow, A S Rosenthal
Apr 1, 1974·The Journal of Experimental Medicine·J C UnkelessE Reich
Feb 1, 1959·The Biochemical Journal·J CONCHIEG A LEVVY
Feb 28, 1959·Nature·J CONCHIEG A LEVVY
Oct 17, 1959·Nature·J CONCHIE, D C MACDONALD
Apr 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·D NATHANS
Mar 20, 1937·The Journal of General Physiology·M L Anson

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Citations

Feb 1, 1976·Agents and Actions·P Davies, A C Allison
Jan 1, 1982·Journal of Periodontal Research·M Weaks-DybvigB R Rifkin
Jul 17, 1975·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P DaviesC J Cardella
Aug 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·B HanebergC O Solberg

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