PMID: 7370768Apr 28, 1980Paper

Changes in central cholinergic neurons in the spontaneously hypertensive rat

Brain Research
C J HelkeD M Jacobowitz

Abstract

The activity of choline acetyltransferase (ChAT) was measured in discrete areas of the brain in 4-, 8- and 12-week-old spontaneously hypertensive rats (SH rats) and age matched Wistar Kyoto (WKY rats) controls. The concentration of acetylcholine (ACh) was also measured in certain hindbrain nuclei of 12 week SH and WKY rats. An increase in the ChAT activity and ACh concentration in the locus coeruleus was detected in 12-week-old SH rats. Decreases in the ChAT activity were found in several hypothalamic nuclei of SH rats, specifically in the paraventricular nucleus of 4-week-old rats, in the dorsomedial nucleus at 8 and 12 weeks and in the posterior hypothalamic nucleus at 12 weeks. Changes in ChAT activity were also detected in 4- and 8-week-old SH rats in the anterior ventral thalamus and in the nucleus gigantocellularis. These results suggest that cholinergic nerve activity in certain rat brain areas, several of which play a role in cardiovascular control, is altered in spontaneously hypertensive rats.

References

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Citations

May 5, 1987·Brain Research·S YamadaE Hayashi
Sep 30, 1983·European Journal of Pharmacology·R ThyagarajanM K Ticku
Mar 18, 1983·European Journal of Pharmacology·L CriscioneW T Talman
Jan 17, 1989·European Journal of Pharmacology·C A Taira, M A Enero
Sep 1, 1983·Neuropharmacology·T Kubo, Y Misu
Mar 1, 1981·Respiration Physiology·S F Gonsalves, H L Borison
Dec 1, 1989·Journal of the Autonomic Nervous System·J P TernauxP Portalier
Dec 1, 1990·Journal of the Autonomic Nervous System·Q Lin, P Li
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·P ChiuR K Mishra
Jan 1, 1985·General Pharmacology·C A Taira, M A Enero
Sep 1, 1984·The Journal of Clinical Investigation·B KennedyM G Ziegler
Jan 1, 1991·Drug Metabolism and Drug Interactions·V M VaragicS Vujnov
Feb 14, 1983·Brain Research·D O Nelson, J A Boulant
Jun 26, 2012·Journal of the Neurological Sciences·Seyed Khosrow TayebatiFrancesco Amenta
Jul 1, 1983·The International Journal of Neuroscience·J S Richardson, E K Chiu
Jun 1, 1993·Hypertension·C OrfilaJ P Girolami
Jul 1, 1985·Hypertension·P G McGuire, T A Twietmeyer
Jun 1, 1990·Circulation Research·M A HajduG L Baumbach
May 1, 1989·The International Journal of Neuroscience·J S Richardson, D M Dunlop
Sep 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·A Jean

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