Changes in central sodium and not osmolarity or lactate induce panic-like responses in a model of panic disorder.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Andre I MoloshA Shekhar

Abstract

Panic disorder is a severe anxiety disorder characterized by recurrent panic attacks that can be consistently provoked with intravenous (i.v.) infusions of hypertonic (0.5 M) sodium lactate (NaLac), yet the mechanism/CNS site by which this stimulus triggers panic attacks is unclear. Chronic inhibition of GABAergic synthesis in the dorsomedial hypothalamus/perifornical region (DMH/PeF) of rats induces a vulnerability to panic-like responses after i.v. infusion of 0.5 M NaLac, providing an animal model of panic disorder. Using this panic model, we previously showed that inhibiting the anterior third ventricle region (A3Vr; containing the organum vasculosum lamina terminalis, the median preoptic nucleus, and anteroventral periventricular nucleus) attenuates cardiorespiratory and behavioral responses elicited by i.v. infusions of NaLac. In this study, we show that i.v. infusions of 0.5 M NaLac or sodium chloride, but not iso-osmolar D-mannitol, increased 'anxiety' (decreased social interaction) behaviors, heart rate, and blood pressure responses. Using whole-cell patch-clamp preparations, we also show that bath applications of NaLac (positive control), but not lactic acid (lactate stimulus) or D-mannitol (osmolar stimulus), increas...Continue Reading

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Citations

Apr 17, 2013·Pflügers Archiv : European journal of physiology·Nina C Donner, Christopher A Lowry
Aug 19, 2014·Neuroscience and Biobehavioral Reviews·Philip L JohnsonAnantha Shekhar
Oct 16, 2014·Neuroscience and Biobehavioral Reviews·Luiz Carlos SchenbergJeyce Willig Quintino-Dos-Santos
Jan 11, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Audrey Franceschi BiagioniNorberto Cysne Coimbra
Mar 9, 2018·Nature Reviews. Neuroscience·Pierre J Magistretti, Igor Allaman
Sep 16, 2017·Experimental and Therapeutic Medicine·Liying YangFeng Tian

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