Abstract
Whereas several studies have used functional magnetic resonance imaging (fMRI) to investigate motor recovery, whether therapy to decrease post-stroke hypertonus alters central motor patterns remains unclear. In this study, we used continuous electromyography (EMG)-fMRI to investigate possible changes in movement-related brain activation in patients receiving Botulinum toxin (BoNT-A) for hand-muscle hypertonus after chronic stroke. We studied eight stroke patients all of whom had hemiparesis and associated upper-limb hypertonus. All patients underwent an fMRI-EMG recording and clinical-neurological assessment before BoNT-A and 5 weeks thereafter. The handgrip motor task during imaging was fixed across both patients and controls. The movements were metronome paced, movement amplitude and force were controlled with a plastic orthosis, dynamometer and EMG recording. An age-matched control group was recruited from among healthy volunteers underwent the same fMRI-EMG recording. Before BoNT-A, while patients moved the paretic hand, fMRI detected wide bilateral activation in the sensorymotor areas (SM1), in the supplementary motor area (SMA) and cerebellum. After BoNT-A blood oxygenation level-dependent (BOLD) activation decreased in i...Continue Reading
References
May 1, 1992·Annals of Neurology·C WeillerR S Frackowiak
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottV Hertzberg
Jan 1, 1980·European Neurology·G DemeurisseE Robaye
May 1, 1996·Neurology·D M SimpsonE P Monaghan
Jun 21, 1996·Science·R J NudoG W Milliken
Apr 1, 1997·Brain : a Journal of Neurology·A O Ceballos-BaumannD J Brooks
Oct 23, 1997·Neuroreport·P GirlandaC Messina
Nov 28, 1997·Journal of Child Neurology·H Shamoto, H T Chugani
Dec 31, 1997·Stroke; a Journal of Cerebral Circulation·S C CramerB R Rosen
Feb 6, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·P KanovskýI Rektor
Jun 10, 1998·Brain : a Journal of Neurology·M L ByrnesF L Mastaglia
Mar 4, 2000·Stroke; a Journal of Cerebral Circulation·R S MarshallR L DeLaPaz
Aug 31, 2001·Neurorehabilitation and Neural Repair·S C CramerB R Rosen
Mar 26, 2002·Brain : a Journal of Neurology·James R CareyKamil Ugurbil
Jun 6, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·P ManganottiA Fiaschi
Aug 27, 2002·Clinical Rehabilitation·C L WatkinsA K Sharma
Nov 14, 2002·Brain : a Journal of Neurology·Heidi Johansen-BergPaul M Matthews
Mar 7, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Giovanni Abbruzzese, Alfredo Berardelli
May 10, 2003·Stroke; a Journal of Cerebral Circulation·Cinzia Calautti, Jean-Claude Baron
Dec 10, 2003·CNS Drugs·Stefan Hesse, Cordula Werner
Mar 18, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Antonio CurràAlfredo Berardelli
Jun 3, 2004·Annals of Neurology·Nick S WardRichard S J Frackowiak
May 10, 2005·NeuroImage·Hiske van DuinenNatasha Maurits
May 30, 2006·NeuroImage·Mark P RichardsonPeter Brown
Oct 19, 2006·NeuroImage·Cinzia CalauttiJean-Claude Baron
Citations
Nov 22, 2011·Experimental Brain Research·Takashi IidaMisao Kawara
Jan 20, 2011·The International Journal of Neuroscience·Andy Pickett, Raymond L Rosales
Mar 6, 2016·Journal of the Neurological Sciences·Tomáš VeverkaPetr Kaňovský
Sep 29, 2011·Disability and Rehabilitation·Chetan P PhadkeChris Boulias
Sep 27, 2014·Journal of the Neurological Sciences·Tomáš VeverkaPetr Kaňovský
Aug 11, 2012·Archives of Physical Medicine and Rehabilitation·Dongyu WuYing Yuan
Jun 13, 2012·Journal of the Neurological Sciences·Tomáš VeverkaPetr Kaňovský
Jul 12, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·P ManganottiA Fiaschi
Jan 4, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Zuzana TomášováPetr Kaňovský
Oct 6, 2014·Annals of Physical and Rehabilitation Medicine·P MarqueI Loubinoux
Apr 18, 2015·BMC Neurology·Ulla BergfeldtPer Julin
Aug 10, 2013·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·J BoudarhamR Zory
Aug 8, 2014·Stroke Research and Treatment·Svetlana PundikJanis J Daly
Jan 10, 2019·Toxins·David WeiseMarkus Naumann
Sep 25, 2018·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Emanuela FormaggioFrancesco Piccione
Jul 18, 2018·Frontiers in Neurology·Frederique M C BoonstraScott C Kolbe
May 31, 2019·Frontiers in Neurology·Tomáš VeverkaPetr Hluštík
Apr 20, 2019·Scientific Reports·Anthony HowardSimon P Frostick
Feb 23, 2020·American Journal of Physical Medicine & Rehabilitation·Franco MolteniAlessandra Del Felice
Mar 7, 2021·Toxins·Pavel HokPetr Kaňovský