Changes in cerebral activity after decreased upper-limb hypertonus: an EMG-fMRI study

Magnetic Resonance Imaging
Paolo ManganottiAntonio Fiaschi

Abstract

Whereas several studies have used functional magnetic resonance imaging (fMRI) to investigate motor recovery, whether therapy to decrease post-stroke hypertonus alters central motor patterns remains unclear. In this study, we used continuous electromyography (EMG)-fMRI to investigate possible changes in movement-related brain activation in patients receiving Botulinum toxin (BoNT-A) for hand-muscle hypertonus after chronic stroke. We studied eight stroke patients all of whom had hemiparesis and associated upper-limb hypertonus. All patients underwent an fMRI-EMG recording and clinical-neurological assessment before BoNT-A and 5 weeks thereafter. The handgrip motor task during imaging was fixed across both patients and controls. The movements were metronome paced, movement amplitude and force were controlled with a plastic orthosis, dynamometer and EMG recording. An age-matched control group was recruited from among healthy volunteers underwent the same fMRI-EMG recording. Before BoNT-A, while patients moved the paretic hand, fMRI detected wide bilateral activation in the sensorymotor areas (SM1), in the supplementary motor area (SMA) and cerebellum. After BoNT-A blood oxygenation level-dependent (BOLD) activation decreased in i...Continue Reading

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Citations

Nov 22, 2011·Experimental Brain Research·Takashi IidaMisao Kawara
Jan 20, 2011·The International Journal of Neuroscience·Andy Pickett, Raymond L Rosales
Mar 6, 2016·Journal of the Neurological Sciences·Tomáš VeverkaPetr Kaňovský
Jul 12, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·P ManganottiA Fiaschi
Jan 4, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Zuzana TomášováPetr Kaňovský
Oct 6, 2014·Annals of Physical and Rehabilitation Medicine·P MarqueI Loubinoux
Aug 10, 2013·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·J BoudarhamR Zory
Jan 10, 2019·Toxins·David WeiseMarkus Naumann
Sep 25, 2018·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Emanuela FormaggioFrancesco Piccione
Jul 18, 2018·Frontiers in Neurology·Frederique M C BoonstraScott C Kolbe
Feb 23, 2020·American Journal of Physical Medicine & Rehabilitation·Franco MolteniAlessandra Del Felice
Mar 7, 2021·Toxins·Pavel HokPetr Kaňovský

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Botulism (ASM)

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

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Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

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