PMID: 8967461May 1, 1996Paper

Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia

The American Journal of Physiology
S G HasselbalchOlaf B Paulson

Abstract

During starvation, brain energy metabolism in humans changes toward oxidation of ketone bodies. To investigate if this shift is directly coupled to circulating blood concentrations of ketone bodies, we measured global cerebral blood flow (CBF) and global cerebral carbohydrate metabolism with the Kety-Schmidt technique before and during intravenous infusion with ketone bodies. During acute hyperketonemia (mean beta-hydroxybutyrate blood concentration 2.16 mM), cerebral uptake of ketones increased from 1.11 to 5.60 mumol.100 g-1.min-1, counterbalanced by an equivalent reduction of the cerebral glucose metabolism from 25.8 to 17.2 mumol.100 g-1.min-1, with the net result being an unchanged cerebral uptake of carbohydrates. In accordance with this, global cerebral oxygen metabolism was not significantly altered (144 vs. 135 mumol.100 g-1.min-1). The unchanged global cerebral metabolic activity was accompanied by a 39% increase in CBF from 51.0 to 70.9 ml.100 g-1.min-1. Regional analysis of the glucose metabolism by positron emission tomography-[18F]fluoro-2-deoxy-D-glucose indicated that mesencephalon does not oxidize ketone bodies to the same extent as the rest of the brain. It was concluded that the immediate oxidation of ketone ...Continue Reading

Citations

Jul 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bjørn QuistorffJohannes J Van Lieshout
Apr 11, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patricia ClementEric Achten
Feb 6, 2020·Current Pharmaceutical Design·Jeremy J WalshJonathan P Little
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·G BlomqvistK Ekberg
Feb 8, 2007·American Journal of Physiology. Endocrinology and Metabolism·Michelle A PuchowiczJoseph C LaManna
Nov 26, 2020·International Journal of Molecular Sciences·Nicole Jacqueline JensenJørgen Rungby
Jan 13, 2021·International Journal of Molecular Sciences·Laurent SuissaSabine Lindenthal
Mar 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·Lilianne R Mujica-ParodiKieran Clarke
Apr 28, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mélanie FortierStephen C Cunnane
Oct 12, 2021·Annual Review of Nutrition·Patrycja Puchalska, Peter A Crawford
Oct 28, 2021·The Journal of Physiology·Hannah G CaldwellPhilip N Ainslie

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