Changes in cerebral perfusion in extremely LBW infants during the first 72 h after birth

Pediatric Research
Takeshi TakamiAkinori Hoshika

Abstract

Cerebral perfusion and its relation with systemic circulation in extremely LBW (ELBW) infants in the early neonatal period are not well understood. The cerebral tissue oxygenation index (TOI) and cerebral fractional tissue oxygen extraction (FTOE) were monitored in stable 16 ELBW infants (GA <29 wk) using near-infrared spectroscopy (NIRS) at 3-6, 12, 18, 24, 36, 48, and 72 h after birth. The left ventricular end-systolic wall stress (ESWS), left ventricular ejection fraction (LVEF), left ventricular cardiac output (LVCO), and superior vena cava (SVC) flow were also measured simultaneously using echocardiography. The ESWS increased till 18 h and then decreased; LVEF, LVCO, and SVC flow decreased till 12 h and increased thereafter. The TOI decreased till 12 h and correlated with SVC flow; FTOE increased until 12 h and then decreased. These changes in variables of NIRS and echocardiographic measurements contrasted to changes in mean arterial blood pressure (MABP), which showed trends of continuous and gradual increase after birth. We conclude that even stable ELBW infants undergo evident transitional changes in cerebral oxygenation and perfusion in the early postnatal period, which may reflect changes in cardiac function and cardi...Continue Reading

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Citations

Jul 31, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Anna SellmerTine Brink Henriksen
Apr 12, 2016·Frontiers in Pediatrics·Daragh FinnEugene M Dempsey
Sep 5, 2017·The Cochrane Database of Systematic Reviews·Simon Hyttel-SorensenChristian Gluud
May 16, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Agnese De CarliGorm Greisen
Jun 8, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sachiko IwataOsuke Iwata
Jun 13, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Nariae BaikGerhard Pichler

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