Changes in cholesterol metabolism during acute upper gastrointestinal bleeding: liver cirrhosis and non cirrhosis compared

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Vladimír HrabovskýZdenek Svagera

Abstract

Cholesterol is derived via de novo synthesis and dietary absorption. Both processes can be monitored by determination of non-cholesterol sterol concentrations (lathosterol for synthesis; sitosterol and campesterol for absorption). The hypocholesterolemia that occurs during acute illness is a result of a multifactorial inability to compensate for the increased needs for this metabolite. The aim of this study was to examine the plasma cholesterol profile and both processes of cholesterol acquisition during acute upper gastrointestinal haemorrhage with emphasis on liver cirrhosis. Thirty five patients with acute upper gastrointestinal bleeding (cirrhosis n=14, non-cirrhosis n=21) were evaluated over a 6 day period. The control cohort consisted of 100 blood donors. Serum concentrations of total, LDL (low-density lipoprotein) and HDL (high-density lipoprotein) cholesterol were measured enzymatically. Sterol concentrations were analysed using gas chromatography, data were statistically analysed. In all patients, we found lower plasma levels of total cholesterol (P Conclusion: Our results showed substantial abnormalities in the cholesterol plasma profile including both the processes of cholesterol acquisition in patients with upper ac...Continue Reading

References

Jan 1, 1986·The American Journal of Clinical Nutrition·R S Tilvis, T A Miettinen
Mar 1, 1996·Gut·T A RockallT C Northfield
Aug 7, 1998·European Journal of Clinical Investigation·M PfohlG R Thompson
Nov 1, 2000·Critical Care Medicine·P FraunbergerD Seidel
Jan 5, 2002·Journal of Chromatography. a·A Kuksis
Jan 28, 2004·Wiener klinische Wochenschrift·Bohumil BakalarZdenek Zadak
Mar 2, 2005·Pharmacology & Therapeutics·Thomas SudhopKlaus von Bergmann
Jul 5, 2005·The American Journal of Cardiology·Klaus von BergmannDieter Lütjohann
Oct 16, 2009·Journal of Critical Care·Carlo ChiarlaGennaro Nuzzo
Mar 22, 2013·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Vera E ValkhoffErnst J Kuipers
Oct 29, 2013·Best Practice & Research. Clinical Gastroenterology·Iyad Khamaysi, Ian M Gralnek

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.