PMID: 1202024Dec 1, 1975Paper

Changes in cholinergic synaptic vesicle populations and the ultrastructure of the nerve terminal membranes of Narcine brasiliensis electron organ stimulated to fatigue in vivo

The Journal of Cell Biology
A F BoyneT H Williams

Abstract

Narcine brasiliensis electric organ was stimulated to fatigue in vivo. Electrical display of organ output and biochemical assay of bound acetylcholine (ACh) and ATP in isolated vesicles were used to assess the state of fatigue relative to denervated control organs of the same fish. A morphometric analysis of the fate of the synaptic vesicle populations in the nerve terminals was carried out. Statistically significant morphological changes in vesicle populations and plasma membranes were observed between control and fatigued electroplaque stacks from individual fish. Pooled data from several fish were used to evaluate the possible role of the different vesicle types in neurotransmission. Fatigue resulted in the loss of 49% of the total vesicle population and a 76% loss of vesicles with bound calcium (Ca). An approximately equivalent increase in the nerve-terminal plasma membrane area was measured. This was predominantly in the form of fingerlike protrusions and/or invaginations of the terminals which were present in the control organs but which were significantly increased by stimulation. Vesicle attachments to the nerve terminal membrane were reduced by 90%. This suggests that the failure in transmission may be due to reduction...Continue Reading

References

Dec 1, 1974·The Journal of Cell Biology·A F BoyneT H Williams
Jun 1, 1974·The Journal of Cell Biology·A L PolitoffG D Pappas
Jan 1, 1965·The Journal of Cell Biology·M N SHERIDAN

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Citations

Apr 1, 1982·Journal of Neurocytology·A M Mercurio, E Holtzman
Jan 1, 1979·Progress in Neurobiology·M IsraelR Manaranche
Jan 1, 1979·Neuroscience·H Zimmermann
Jun 1, 1978·Journal of Neurochemistry·J B SuszkiwV P Whittaker
Feb 12, 2011·Hearing Research·Jahn N O'NeilDavid K Ryugo
Oct 11, 2014·Cell and Tissue Research·David Ryugo
Nov 1, 1995·Neurochemical Research·V P Whittaker, S Kelić
Jan 29, 1996·The Journal of Comparative Neurology·D K RyugoT Pongstaporn

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