PMID: 6402454Mar 15, 1983Paper

Changes in chromatin composition associated with hormone-dependent mammary tumor regression

International Journal of Cancer. Journal International Du Cancer
R G Goya, Y E Sosa


The chemical composition of chromatin from dimethylbenz(a)anthracene (DMBA)-induced mammary tumors was compared in growing and regressing neoplasms. Tumor regression was induced by 2-bromo-alpha-ergocryptine (CB-154) administration to the tumor-bearing rats. Seventy percent of the neoplasms showed a sharp fall in the levels of 3H-thymidine incorporation into DNA after 7-8 days of treatment (1 mg CB-154/day). These CB-154-responsive tumors showed a significant increase in nonhistone chromosomal proteins (NHCP) relative to DNA, while the histone fraction remained constant. Non-responsive tumors showed no change in their chromatin composition. Low doses of ovine prolactin (18 IU) given together with CB-154 (1 mg) were able to prevent the effects of the latter on both DNA synthesis and chromatin composition of DMBA- induced mammary tumors. High doses of hormone (40 IU) produced a two-fold increase in the tumors' DNA synthesis irrespective of the simultaneous administration of 1- or 2-mg doses of CB-154. This high dose of hormone was also able to prevent the effects of CB-154 on chromatin composition of the tumors. We conclude that the above effects of CB-154 are exerted mainly, if not exclusively, through the inhibition of prolacti...Continue Reading


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