PMID: 8594304Jan 1, 1996Paper

Changes in citrate concentration in the mouse uterus with experimentally-induced adenomyosis

Life Sciences
A IizukaH Nagasawa

Abstract

Components of the uterine fluid in mice with experimentally-induced adenomyosis and in controls were examined by proton nuclear magnetic resonance spectroscopy. One of the components was markedly different in mice with adenomyosis. As this component was estimated to be citrate by comparison with authentic samples (standard spectrum), its levels in uterine fluid, uterine tissue and blood were determined by enzymatic analysis. The fluid obtained from the uterus with adenomyosis showed significantly lower concentration of citrate than that from normal uterus. However, the uterine tissue concentration was significantly higher in the experimental mice with adenomyosis. There was no difference in the blood citrate level between the experimental and the control groups. Since adenomyosis was induced by chronic hyperprolactinemia, the change of citrate level in the uterus with this lesion might imply some effects of prolactin (PRL) on metabolism and/or secretion of citrate. However, in normal mice, no significant change was demonstrated in uterine citrate concentration after short-term experimental modulation of the circulating PRL level. Thus, it is unlikely that PRL can regulate directly citrate metabolism in the uterus, indicating so...Continue Reading

References

Mar 1, 1989·Journal of Reproduction and Fertility·D R BrigstockK D Brown
Mar 1, 1988·Journal of Reproduction and Fertility·R M Roberts, F W Bazer
Apr 1, 1987·Biology of Reproduction·C G Pantazis, E F Howard
Mar 1, 1992·Physical Review C: Nuclear Physics·Y FujitaH Folger

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Citations

Dec 4, 2015·Mass Spectrometry Reviews·Huiliang YangYuquan Wei

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