Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis

American Journal of Respiratory and Critical Care Medicine
Harold R CollardKevin K Brown

Abstract

There is significant heterogeneity in survival time among patients with idiopathic pulmonary fibrosis. Studies of baseline clinical and physiologic variables as predictors of survival time have reported inconsistent results. We evaluated the predictive value of changes in clinical and physiologic variables over time for survival time in 81 patients with biopsy-proven idiopathic pulmonary fibrosis. Six-month changes in dyspnea score, total lung capacity, thoracic gas volume, FVC, FEV1, diffusing capacity of carbon monoxide, partial pressure of arterial oxygen, oxygen saturation, and alveolar-arterial oxygen gradient were predictive of survival time even after adjustment for baseline values. Analyses were repeated on 51 patients with 12-month change data. Twelve-month changes in dyspnea score, total lung capacity, FVC, partial pressure of arterial oxygen, oxygen saturation, and alveolar-arterial oxygen gradient were predictive of survival time after adjustment for baseline values. Evaluation of changes in clinical and physiological variables over 6 and 12 months may provide clinicians with more accurate prognostic information than baseline values alone.

References

Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·F X McCormackF X McCormac
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·D A SchwartzG W Hunninghake
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·J A BjorakerK P Offord
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·S E GayF J Martinez
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·A L Katzenstein, J L Myers
Jul 4, 2001·American Journal of Respiratory and Critical Care Medicine·N MogulkocUNKNOWN Greater Manchester Pulmonary Fibrosis Consortium
Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·G W HunninghakeM Millard
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·T E KingR M Cherniack
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·T E KingR M Cherniack
Nov 20, 2001·Thorax·N MogulkocUNKNOWN Greater Manchester Pulmonary Fibrosis Consortium
Jun 1, 1949·Journal of Applied Physiology·R L RILEY, A COURNAND

❮ Previous
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Citations

Feb 28, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Yukihiro UmedaHidehiko Okazawa
Nov 25, 2005·The New England Journal of Medicine·Maurits DemedtsUNKNOWN IFIGENIA Study Group
Sep 17, 2008·Rheumatology·J Behr, D E Furst
Aug 24, 2006·Current Opinion in Pulmonary Medicine·Om P Sharma
Apr 19, 2013·Journal of Cardiopulmonary Rehabilitation and Prevention·Vicki Johnson-WarringtonSally Singh
Jun 25, 2009·Current Opinion in Pulmonary Medicine·Stephen K Frankel, Marvin I Schwarz
Jul 16, 2011·Current Opinion in Pulmonary Medicine·Joyce S LeeHarold R Collard
Nov 5, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Marco MuraMario Fabbri
Mar 5, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ross C KlingsbergJoseph A Lasky
Jun 16, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tristan J HuieStephen K Frankel
Oct 6, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Linda PeelenPaul Bresser
Oct 16, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jeffrey J SwigrisSteven D Nathan
Aug 4, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ryo KozuHideaki Senjyu
Jan 4, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tamera J CorteAthol U Wells
Jan 20, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sakae HommaUNKNOWN Japan NAC Clinical Study Group
Mar 7, 2013·Thorax·Ganesh Raghu, David R Thickett
Oct 9, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Payal K NaikUNKNOWN COMET Investigators
Sep 8, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·James F GuentherGilbert F Morris
Oct 8, 2005·Respiration; International Review of Thoracic Diseases·Rollin P TabuenaMichiaki Mishima
Feb 18, 2006·Respiration; International Review of Thoracic Diseases·Marco MuraMario Fabbri
Apr 27, 2004·American Journal of Respiratory and Critical Care Medicine·Gabriel ThabutKevin K Brown
Jan 11, 2005·American Journal of Respiratory and Critical Care Medicine·Yangjin JegalThomas V Colby
Dec 8, 2004·American Journal of Respiratory and Critical Care Medicine·Isao ItoMichiaki Mishima
Jan 25, 2005·American Journal of Respiratory and Critical Care Medicine·Arata AzumaShoji Kudoh
Oct 22, 2005·American Journal of Respiratory and Critical Care Medicine·Patrizia PignattiGianna Moscato
Jul 11, 2006·American Journal of Respiratory and Critical Care Medicine·Kevin R FlahertyFernando J Martinez
Jun 17, 2006·American Journal of Respiratory and Critical Care Medicine·David J LedererSteven M Kawut
Jan 27, 2007·American Journal of Respiratory and Critical Care Medicine·Steven D NathanRubin M Tuder
Jun 19, 2007·American Journal of Respiratory and Critical Care Medicine·Jason H T BatesBéla Suki
Mar 27, 2007·American Journal of Respiratory and Critical Care Medicine·Athol U Wells, Cory M Hogaboam
Dec 17, 2008·American Journal of Respiratory and Critical Care Medicine·Charlene D FellKevin R Flaherty
Oct 24, 2008·American Journal of Respiratory and Critical Care Medicine·Robert M Jackson, Charlene D Fell
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Oct 12, 2010·American Journal of Respiratory and Critical Care Medicine·Brett LeyTalmadge E King
Dec 7, 2010·American Journal of Respiratory and Critical Care Medicine·Roland M du BoisTalmadge E King
May 28, 2011·American Journal of Respiratory and Critical Care Medicine·Roland M du BoisTalmadge E King
Apr 9, 2011·American Journal of Respiratory and Critical Care Medicine·Talmadge E KingJuergen Behr
Sep 24, 2011·American Journal of Respiratory and Critical Care Medicine·Roland M du BoisAthol U Wells
Aug 17, 2011·American Journal of Respiratory and Critical Care Medicine·Athol U WellsFernando J Martinez
Dec 17, 2011·American Journal of Respiratory and Critical Care Medicine·Jürgen Behr
Apr 17, 2012·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuKevin K Brown
Aug 28, 2003·American Journal of Respiratory and Critical Care Medicine·Paul W Noble, David G Morris
Jan 14, 2004·American Journal of Respiratory and Critical Care Medicine·Martin J Tobin

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