May 30, 2003

Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis

American Journal of Respiratory and Critical Care Medicine
Harold R CollardKevin K Brown

Abstract

There is significant heterogeneity in survival time among patients with idiopathic pulmonary fibrosis. Studies of baseline clinical and physiologic variables as predictors of survival time have reported inconsistent results. We evaluated the predictive value of changes in clinical and physiologic variables over time for survival time in 81 patients with biopsy-proven idiopathic pulmonary fibrosis. Six-month changes in dyspnea score, total lung capacity, thoracic gas volume, FVC, FEV1, diffusing capacity of carbon monoxide, partial pressure of arterial oxygen, oxygen saturation, and alveolar-arterial oxygen gradient were predictive of survival time even after adjustment for baseline values. Analyses were repeated on 51 patients with 12-month change data. Twelve-month changes in dyspnea score, total lung capacity, FVC, partial pressure of arterial oxygen, oxygen saturation, and alveolar-arterial oxygen gradient were predictive of survival time after adjustment for baseline values. Evaluation of changes in clinical and physiological variables over 6 and 12 months may provide clinicians with more accurate prognostic information than baseline values alone.

  • References19
  • Citations278

References

  • References19
  • Citations278

Citations

Mentioned in this Paper

Molecular Oxygen Saturation
Pulmonary Fibrosis
Severity of Illness Index
Incidence Studies
Oxygen Saturation Measurement
Dissecting Aneurysm of the Thoracic Aorta
Longitudinal Survey
Idiopathic Pulmonary Fibrosis
Chest
Lung Capacities

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