Changes in clot lysis levels of reteplase and streptokinase following continuous wave ultrasound exposure, at ultrasound intensities following attenuation from the skull bone.

BMC Cardiovascular Disorders
Bjarne Madsen HärdigAnders Roijer

Abstract

Ultrasound (US) has been used to enhance thrombolytic therapy in the treatment of stroke. Considerable attenuation of US intensity is however noted if US is applied over the temporal bone. The aim of this study was therefore to explore possible changes in the effect of thrombolytic drugs during low-intensity, high-frequency continuous-wave ultrasound (CW-US) exposure. Clots were made from fresh venous blood drawn from healthy volunteers. Each clot was made from 1.4 ml blood and left to coagulate for 1 hour in a plastic test-tube. The thrombolytic drugs used were, 3600 IU streptokinase (SK) or 0.25 U reteplase (r-PA), which were mixed in 160 ml 0.9% NaCl solution. Continuous-wave US exposure was applied at a frequency of 1 MHz and intensities ranging from 0.0125 to 1.2 W/cm2. For each thrombolytic drug (n = 2, SK and r-PA) and each intensity (n = 9) interventional clots (US-exposed, n = 6) were submerged in thrombolytic solution and exposed to CW-US while control clots (also submerged in thrombolytic solution, n = 6) were left unexposed to US.To evaluate the effect on clot lysis, the haemoglobin (Hb) released from each clot was measured every 20 min for 1 hour (20, 40 and 60 min). The Hb content (mg) released was estimated by sp...Continue Reading

References

Nov 1, 1992·The Journal of Clinical Investigation·C W FrancisV J Marder
Jan 1, 1983·Advances in Clinical Chemistry·E J van Kampen, W G Zijlstra
Sep 1, 1995·Stroke; a Journal of Cerebral Circulation·Y KugeY Miyake
Oct 1, 1995·Circulation·D V Sakharov, D C Rijken
Jan 1, 1995·Ultrasound in Medicine & Biology·A M NilssonS B Olsson
Feb 4, 1999·The British Journal of Ophthalmology·J LarssonS B Olsson
May 13, 1999·Ultrasound in Medicine & Biology·S BehrensM Hennerici
Feb 13, 2002·Ultrasound in Medicine & Biology·S BehrensM Hennerici
Apr 30, 2002·Ultrasound in Medicine & Biology·Valentina SuchkovaCharles W Francis
Jan 15, 2003·Journal of Vascular and Interventional Radiology : JVIR·Charles P SembaThomas Patapoff
Apr 12, 2003·Journal of Vascular and Interventional Radiology : JVIR·Charles P SembaThomas Patapoff
May 27, 2003·Cardiovascular Drugs and Therapy·Gil Zvi ShlamovitzYochai Birnbaum
Jun 5, 2003·Annals of Neurology·Jürgen EggersGünter Seidel
Jul 10, 2003·Lancet Neurology·Michael Daffertshofer, Michael Hennerici
Aug 14, 2003·The American Journal of Cardiology·Mauricio G CohenLiliana R Grinfeld
Dec 31, 2003·Biotechnology Advances·Anirban BanerjeeU C Banerjee
Apr 21, 2004·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Andrei V AlexandrovUNKNOWN CLOTBUST Investigators
Jul 17, 2004·Annual Review of Biomedical Engineering·Diane Dalecki
Nov 19, 2004·The New England Journal of Medicine·Andrei V AlexandrovUNKNOWN CLOTBUST Investigators
Dec 14, 2004·Ultrasound in Medicine & Biology·Marlien PietersDingeman C Rijken
Dec 14, 2004·Stroke; a Journal of Cerebral Circulation·Stefan PfaffenbergerMichael Gottsauner-Wolf
Jun 7, 2005·Ultrasound in Medicine & Biology·Simon SchäferFrank A Flachskampf
Feb 16, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Bjarne Madsen HärdigS Bertil Olsson
Mar 21, 2006·Thrombosis Research·Azita Soltani, Charles Soliday
Nov 18, 2006·Journal of Thrombosis and Thrombolysis·Adinarayana KunamneniPoluri Ellaiah
Mar 6, 2007·Ultrasound in Medicine & Biology·Jason M MeunierGeorge J Shaw
Sep 15, 2007·Thrombosis Research·Christy K HollandGeorge J Shaw
Sep 27, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jaroslaw KrejzaScott Kasner

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Citations

Nov 28, 2012·Journal of Thrombosis and Thrombolysis·Igor AdzerikhoAnatoly Kulak
May 15, 2013·Therapeutic Hypothermia and Temperature Management·Jason M MeunierGeorge J Shaw
Sep 4, 2010·Thrombosis Research·George J ShawChristy K Holland
Mar 4, 2020·Sensors·Leela Goel, Xiaoning Jiang
Feb 6, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Zuojun WangMasayuki Yokoyama

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