Changes in Coagulation and Platelet Activation Markers Following Transcatheter Left Atrial Appendage Closure

The American Journal of Cardiology
Josep Rodés-CabauJean Champagne

Abstract

The recommendations for antithrombotic treatment after left atrial appendage closure (LAAC) remain empirical, and no data exist on the changes in hemostatic markers associated with LACC. The objective of the present study is to determine the presence, degree, and timing of changes in the markers of platelet and coagulation activation after LAAC. Forty-three patients (mean age 76 ± 9 years, 23 men) with atrial fibrillation who underwent successful LACC with the Watchman (n = 27) or Amplatzer Cardiac Plug (n = 16) devices were included in the study. Patients received antiplatelet therapy after LAAC (aspirin + clopidogrel: 27 patients; single antiplatelet therapy with aspirin or clopidogrel: 16 patients). Prothrombin fragment 1+2 and thrombin-antithrombin III were used as markers of coagulation activation, and soluble P-selectin and soluble CD40 ligand were used as markers of platelet activation. Measurements of all hemostatic markers were performed at baseline just before the procedure, followed by days 7, 30, and 180 after LAAC. Prothrombin fragment 1+2 and thrombin-antithrombin levels increased from 0.27 nmol/L and 4.68 ng/ml, respectively, at baseline to peak values of 0.43 nmol/L and 9.76 ng/ml, respectively, at 7 days, parti...Continue Reading

References

Mar 21, 2003·The New England Journal of Medicine·Christopher HeeschenUNKNOWN CAPTURE Study Investigators
Jul 29, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·John L Bass

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Citations

Nov 18, 2017·Circulation. Cardiovascular Interventions·Lluis Asmarats, Josep Rodés-Cabau
Apr 4, 2019·Pacing and Clinical Electrophysiology : PACE·Ozcan OzekeDursun Aras
Aug 11, 2020·Circulation. Cardiovascular Interventions·Lluis AsmaratsJosep Rodés-Cabau
Apr 28, 2020·Current Pharmaceutical Design·Maria DrakopoulouDimitrios Tousoulis
Dec 1, 2020·The Journal of International Medical Research·Shu-Yue LiHang Xu
Nov 26, 2021·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Nicolas DogninJean Champagne

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