Changes in cognition precede changes in HRQoL among HIV+ males: Longitudinal analysis of the multicenter AIDS cohort study

Neuropsychology
Jacob D JonesCharles H Hinkin

Abstract

Despite treatment-related improvements in morbidity and mortality, HIV-1-infected (HIV+) individuals continue to face a wide range of HIV-associated medical and HIV-associated neurocognitive disorders. Little is known about the impact of cognitive impairment on patients' health-related quality of life (HRQoL). To address this, the current study examined the longitudinal relationship between cognitive functioning and HRQoL among HIV+ individuals. The sample consisted of 1,306 HIV+ men enrolled in the Multicenter AIDS Cohort Study. Participants received biannual assessments of cognitive functioning (including tests of processing speed, executive functioning, attention/working memory, motor functioning, learning, and memory) and completed questionnaires assessing HRQoL and depression. Multilevel models were used to examine the longitudinal and cross-lagged relationship between HRQoL and cognition, independent of depression and HIV disease severity. There was a significant relationship between HRQoL and cognitive functioning both between and within subjects. Specifically, individuals who reported better HRQoL reported better cognitive functioning, and longitudinal change in cognition was positively related to change in HRQoL. There...Continue Reading

Citations

Mar 21, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Emily W PaolilloDavid J Moore
Apr 30, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ni Sun-SuslowDavid J Moore
Jul 22, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ni Sun-SuslowDavid J Moore
Aug 28, 2021·Journal of Neurovirology·Jacqueline Samantha WomersleySian Megan Joanna Hemmings
Sep 28, 2021·International Journal of STD & AIDS·Zaeema NaveedLorena Baccaglini
Nov 26, 2021·Current HIV/AIDS Reports·Samuel WilsonVictor Valcour

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