The clinical hallmark of Alzheimer's disease (AD) is a gradual decline in cognitive function. For the majority of patients the initial symptom is an impairment in episodic memory, i.e., the ability to learn and retain new information. This is followed by impairments in other cognitive domains (e.g., executive function, language, spatial ability). This impairment in episodic memory is evident among individuals with mild cognitive impairment (MCI) and can be used to predict likelihood of progression to dementia, particularly in association with AD biomarkers. Additionally, cognitively normal individuals who are likely to progress to mild impairment tend to perform more poorly on tests of episodic memory than do those who remain stable. This cognitive presentation is consistent with the pathology of AD, showing neuronal loss in medial temporal lobe structures essential for normal memory. Similarly, there are correlations between magnetic resonance imaging (MRI) measures of medial temporal lobe structures and memory performance among individuals with mild cognitive impairment. There are recent reports that amyloid accumulation may also be associated with memory performance in cognitively normal individuals.
Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type
Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study
Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment
Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease
Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease
Region-specific reduction in brain volume in young adults with perinatal hypoxic-ischaemic encephalopathy
Behaviorally activated mRNA expression profiles produce signatures of learning and enhanced inhibition in aged rats with preserved memory
Cognitive dysfunction and REM sleep behavior disorder: key findings in the literature and preliminary longitudinal findings
Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer's Dementia
Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders
What is the role of spatial processing in the decline of episodic memory in Alzheimer's disease? The "mental frame syncing" hypothesis
Personality, Alzheimer's disease and behavioural and cognitive symptoms of dementia: the PACO prospective cohort study protocol
Contribution of N-methyl-D-aspartate receptors to attention and episodic spatial memory during senescence
The mismatch negativity as an index of cognitive decline for the early detection of Alzheimer's disease
Lipid raft disarrangement as a result of neuropathological progresses: a novel strategy for early diagnosis?
Hypovitaminosis D and executive dysfunction in older adults with memory complaint: a memory clinic-based study
Exercise Training and Functional Connectivity Changes in Mild Cognitive Impairment and Healthy Elders
Impairments in spatial representations and rhythmic coordination of place cells in the 3xTg mouse model of Alzheimer's disease
Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease
Effectiveness of executive function training on mental set shifting, working memory and inhibition in healthy older adults: A double-blind randomized controlled trials
Entorhinal Cortical Deep Brain Stimulation Rescues Memory Deficits in Both Young and Old Mice Genetically Engineered to Model Alzheimer's Disease
Neuronal and glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer's disease.
The neuroprotection of Rattin against amyloid β peptide in spatial memory and synaptic plasticity of rats
Tong Luo Jiu Nao ameliorates Aβ1-40-induced cognitive impairment on adaptive behavior learning by modulating ERK/CaMKII/CREB signaling in the hippocampus
Detection of mild cognitive impairment in middle-aged and older adults with obstructive sleep apnoea
Does Personality Predict Behavioral and Psychological Symptoms of Dementia? Results from PACO Prospective Study
Low Levels of a Urinary Biomarker of Dietary Polyphenol Are Associated with Substantial Cognitive Decline over a 3-Year Period in Older Adults: The Invecchiare in Chianti Study
Association between executive function and the evolution of behavioral disorders in Alzheimer's disease.
Taxifolin prevents β-amyloid-induced impairments of synaptic formation and deficits of memory via the inhibition of cytosolic phospholipase A2 /prostaglandin E2 content
Patterns of cognitive function in middle-aged and elderly Chinese adults-findings from the EMCOA study
Classification and Graphical Analysis of Alzheimer's Disease and Its Prodromal Stage Using Multimodal Features From Structural, Diffusion, and Functional Neuroimaging Data and the APOE Genotype
Clinical and biomarker profiling of prodromal Alzheimer's disease in workpackage 5 of the Innovative Medicines Initiative PharmaCog project: a 'European ADNI study'
Cross-sectional neurocognitive data do not support a transition from fibrofog to Alzheimer disease in fibromyalgia patients
Describing the Sequence of Cognitive Decline in Alzheimer's Disease Patients: Results from an Observational Study
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