PMID: 7335965Dec 1, 1981Paper

Changes in colloid osmotic pressure in patients undergoing cardiothoracic surgery

Resuscitation
P M YeomanS V Rithalia

Abstract

Measurements of plasma colloid osmotic pressure (COP) were made during and for 24 h after normothermic continuous flow cardiopulmonary bypass (CPB) in 20 adults exposed to sudden haemodilution by a crystalloid pump prime solution. Haematocrit, albumin and total protein were also measured. Within 5 min of starting bypass the mean COP fell to 45% pre-bypass value and remained at this level until bypass was discontinued. Following bypass, the oncotic pressure rose rapidly during the first hour to 84% of the prebypass value, and then more slowly until it reached the pre-bypass value 24 h later. The trend seen for plasma proteins and haematocrit was similar but the fall was smaller, 65-70% of the pre-bypass values. This significant difference in fall between plasma protein concentration and directly measured COP is explained by their non-linear relationship. Three patients died soon after bypass. They all showed significantly lower values of COP than the mean for the group as a whole at some stage (P less than 0.05).

References

Mar 1, 1979·Critical Care Medicine·M H WeilV K Puri
Sep 1, 1974·Critical Care Medicine·M H WeilE Jacobson
Jul 1, 1974·Archives of Surgery·A T MartyP A Philips
Jul 1, 1973·Archives of Surgery·A T MartyJ Schauble
Jul 1, 1971·Archives of Surgery·A MartyM Intaglietta
Oct 1, 1980·Anaesthesia·R H Jones
Jan 1, 1981·Journal of Biomedical Engineering·S V RithaliaD E Vence-Pastor

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Citations

Nov 1, 1988·Cardiovascular Drugs and Therapy·K A ReinS Kahn
May 1, 1986·The Annals of Thoracic Surgery·D M CooperF D Loop
Jan 1, 1985·Scandinavian Journal of Thoracic and Cardiovascular Surgery·H LindbergM Abdelnor
May 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·R K ReedO Stokke
Aug 26, 1998·Journal of Cardiothoracic and Vascular Anesthesia·J AukermanR Mosca
Dec 17, 2002·Critical Care Medicine·Lori Q RieggerEdward L Bove

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