Changes in consumption of opioid analgesics in Israel 2009 to 2016: An update focusing on oxycodone and fentanyl formulations

Pharmacoepidemiology and Drug Safety
Alexander M PonizovskyEyal Schwartzberg

Abstract

The purpose of the study is to assess opioid (morphine, methadone, oxycodone, pethidine, and fentanyl) consumption in Israel during 2009 to 2016 and identify recent trends. Data for all treatment settings, private and public, for the years 2009 to 2016, were extracted from the Israel Ministry of Health's Pharmaceutical Administration database. The data were used to calculate defined daily doses (DDD) per 1000 inhabitants per day, of the various drugs. Consumption of the 5 opioids increased by 68%, from 3.40 DDD/1000 inhabitants/day in 2009 to 5.72 DDD/1000 inhabitants/day in 2016. This trend resulted mostly from increases in oxycodone consumption from 0.50 DDD/1000 inhabitants/day to 2.03 DDD/1000 inhabitants/day (namely, 4-fold) and in fentanyl consumption, from 1.09 DDD/1000 inhabitants/day to 2.33 DDD/1000 inhabitants/day (about 2-fold). The use of the 3 remaining opioids decreased substantially as follows: pethidine from 0.03 DDD/1000/day in 2009 to 0.007 DDD/1000 inhabitants/day in 2016 (-67%), methadone from 1.61 DDD/1000 inhabitants/day to 1.20 DDD/1000 inhabitants/day (-25%), and morphine from 0.17 DDD/1000 inhabitants/day to 0.15 DDD/1000 inhabitants/day (-12%). An increasing trend was also observed in the use of oxyco...Continue Reading

References

Nov 7, 2000·Journal for Healthcare Quality : Official Publication of the National Association for Healthcare Quality·M SayersT Dailey
Aug 3, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Hélène Verdoux, Bernard Bégaud
Oct 8, 2008·Experimental and Clinical Psychopharmacology·Andrew RosenblumRussell K Portenoy
Sep 1, 2009·Pharmacoepidemiology and Drug Safety·Denise BoudreauConstance Weisner
Nov 9, 2010·European Journal of Clinical Pharmacology·Alexander M PonizovskyNathan I Cherny
Jul 28, 2011·European Journal of Clinical Pharmacology·Alexander M PonizovskyEdwin E Zvartau
Aug 2, 2012·JAMA : the Journal of the American Medical Association·Lewis S Nelson, Jeanmarie Perrone
Aug 15, 2012·Journal of Pain and Symptom Management·Hsueh-Hsing PanKwua-Yun Wang
Sep 4, 2012·Journal of Opioid Management·Susan C NicholsonDebi Susalka
Mar 27, 2013·Journal of Pain & Palliative Care Pharmacotherapy·Jeffrey A Gudin
Dec 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J ClearyN I Cherny
Dec 5, 2013·Expert Opinion on Drug Delivery·Paul Sloan
Aug 20, 2014·Journal of Pain & Palliative Care Pharmacotherapy·Barbara A HastieJames F Cleary
Mar 27, 2015·Pharmacoepidemiology and Drug Safety·Caitlin KnoxGerald Dal Pan
Jul 5, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·M Soledad CepedaLaura E Wallace
Oct 9, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Kai-Hsiang KangWen-Ing Tsay
Nov 23, 2016·Current Pain and Headache Reports·Daniel KrashinMark Sullivan
Apr 19, 2017·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Lara ZisblattDaniel P Alford
Sep 8, 2017·Pharmacoepidemiology and Drug Safety·Ramin Mojtabai
Oct 3, 2017·Annual Review of Pharmacology and Toxicology·Phil Skolnick
Oct 20, 2017·Anesthesia and Analgesia·Cobin D SoelbergBanu K Ramachandran

❮ Previous
Next ❯

Citations

Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Jun 24, 2020·Peptides·Richard J Bodnar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Clinical Pharmacology
Alexander M PonizovskyNathan I Cherny
Journal of the Formosan Medical Association = Taiwan Yi Zhi
Kai-Hsiang KangWen-Ing Tsay
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Spencer D DornNilay D Shah
European Journal of Clinical Pharmacology
Javier Garcia del PozoVictorina Garcia del Pozo
© 2022 Meta ULC. All rights reserved