PMID: 20647691Jul 22, 2010Paper

Changes in contractile and electrical activity in the ileum of DSS-induced colitis model W/Wv mutant mice

Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
Hiroko MatsuyoshiMiyako Takaki

Abstract

In the ileum of W/W(v) mutant mice (W/W(v)), the absence of interstitial cells of Cajal (ICC) in the myenteric region (ICC-MY), and cross-talk between ICC in the deep muscular region (ICC-DMP) and enteric nitrergic motor nerves leads to irregular spontaneous electrical and contractile activity. The aim of the present study was to reveal changes in this irregular spontaneous electrical and contractile activity in the ileum of dextran sodium sulfate (DSS: m.w. 40,000)-induced colitis model W/W(v) mice. Electrical and contractile activity was recorded with a suction electrode and with both an isometric force transducer and a pressure transducer in the ileum of W/W(v) mice either with DSS-induced colitis (DSS (+)) in the distal colon or without in controls (DSS (-)). Neuronal NO synthase (nNOS) and inducible NO synthase (iNOS) immunoreactivity in the ileum was compared between the following groups of mice: W/W(v) DSS (+), W/W(v) DSS (-), wild type (WT) with (DSS (+)) and WT without DSS-induced colitis (DSS (-)). DSS induced colitis in the distal colon of W/W(v) mice is reduced compared with that in WT mice, despite the reduction in the number of mast cells in the W/W(v) mutants. Irregular contractions in the ileum without colitis w...Continue Reading

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