Changes in crossed spinal reflexes after peripheral nerve injury and repair

Journal of Neurophysiology
Antoni Valero-Cabré, Xavier Navarro

Abstract

We investigated the changes induced in crossed extensor reflex responses after peripheral nerve injury and repair in the rat. Adults rats were submitted to non repaired sciatic nerve crush (CRH, n = 9), section repaired by either aligned epineurial suture (CS, n = 11) or silicone tube (SIL4, n = 13), and 8 mm resection repaired by tubulization (SIL8, n = 12). To assess reinnervation, the sciatic nerve was stimulated proximal to the injury site, and the evoked compound muscle action potential (M and H waves) from tibialis anterior and plantar muscles and nerve action potential (CNAP) from the tibial nerve and the 4th digital nerve were recorded at monthly intervals for 3 mo postoperation. Nociceptive reinnervation to the hindpaw was also assessed by plantar algesimetry. Crossed extensor reflexes were evoked by stimulation of the tibial nerve at the ankle and recorded from the contralateral tibialis anterior muscle. Reinnervation of the hindpaw increased progressively with time during the 3 mo after lesion. The degree of muscle and sensory target reinnervation was dependent on the severity of the injury and the nerve gap created. The crossed extensor reflex consisted of three bursts of activity (C1, C2, and C3) of gradually longe...Continue Reading

References

May 1, 1979·The Journal of Comparative Neurology·M DevorP D Wall
Aug 1, 1979·The Journal of Physiology·B Gustafsson
Mar 1, 1975·Experimental Neurology·M H Clare, W M Landau
Apr 22, 1992·The Journal of Comparative Neurology·T BrännströmJ O Kellerth
May 1, 1990·Journal of the Neurological Sciences·R NavarreteG Vrbová
Sep 1, 1989·Experimental Neurology·S MelvilleR E Coggeshall
Jun 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·H S Milner-BrownR G Lee
Jan 1, 1984·Physiological Reviews·L M Mendell
Nov 1, 1993·Journal of Neurophysiology·T C Cope, B D Clark
Aug 27, 1993·Brain Research·J M Castro-LopesA Coimbra
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·P P SannaM Rende
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Nov 14, 1997·Journal of Neurocytology·M J GrovesF Scaravilli
May 29, 1998·Progress in Neurobiology·H Aldskogius, E N Kozlova
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
Nov 26, 1999·Journal of Physiology, Paris·L M Mendell, J B Munson
Jun 8, 2000·The Journal of Comparative Neurology·T TandrupR E Coggeshall
Jan 11, 2001·Journal of the Peripheral Nervous System : JPNS·E VerdúX Navarro
Aug 29, 1958·The Journal of Physiology·J C ECCLESR R YOUNG
Jul 1, 1942·Journal of Neurology and Psychiatry·E Gutmann, L Guttmann

❮ Previous
Next ❯

Citations

Oct 30, 2007·Experimental Neurology·Maria GroshevaDoychin N Angelov
Apr 23, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Jeffrey E ArleJay L Shils
Jul 27, 2011·The Journal of Physiology·Jonathan F PratherTimothy C Cope
Jul 24, 2007·Progress in Neurobiology·X NavarroAntoni Valero-Cabré
Jan 28, 2005·The European Journal of Neuroscience·Orlando Guntinas-LichiusDoychin N Angelov
Mar 3, 2004·Journal of Neuroscience Research·Guillermo García-AlíasEnrique Verdú
Sep 27, 2015·World Neurosurgery·Neil G SimonMichel Kliot
Feb 6, 2004·Journal of Neurophysiology·Antoni Valero-CabréXavier Navarro
Jan 27, 2010·Nature Reviews. Neurology·Volker Dietz
Feb 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter M Lalley
Jan 20, 2012·Journal of Neural Engineering·James J FitzGeraldJames W Fawcett
Nov 5, 2014·Physiology·Arthur W EnglishPatricia J Ward

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.