PMID: 6113006Dec 5, 1980Paper

Changes in CTP:phosphatidate cytidylyltransferase activity during rabbit lung development

Biochimica Et Biophysica Acta
K J Longmuir, J M Johnston

Abstract

The specific activity of CTP:phosphatidate cytidylyltransferase in rabbit lung and liver microsomes during fetal and neonatal development has been measured. The enzyme in the microsomal fraction of lung tissue has a requirement for Mg2+. Optimal enzyme activity is achieved with phosphatidate (4 mM) and CTP (2 mM) in the presence of ATP (6 mM). Analysis of the reaction products demonstrates that the ATP serves to inhibit the hydrolysis of CTP by microsomal pyrophosphatases. The specific activity of the microsomal enzyme remains constant from day 23 through day 28 of gestation, then increases 2.4-fold between day 28 and day 1 post-partum. The specific activity of the enzyme in the microsomal fraction from rabbit liver tissue does not change significantly, and is less than in the lung tissue at all stages of development. The increase in the activity of microsomal CTP:phosphatidate cytidylyltransferase in lung tissue is concurrent with the appearance of pulmonary surfactant containing phosphatidylglycerol during the perinatal period of rabbit lung development.

References

Sep 2, 1975·Biochemical and Biophysical Research Communications·H L SpitzerJ M Johnston
Jul 1, 1976·American Journal of Obstetrics and Gynecology·M HallmanL Gluck
Sep 20, 1976·Biochemical and Biophysical Research Communications·K Y HostetlerH P Morris
Dec 22, 1978·Biochimica Et Biophysica Acta·H L Spitzer, J M Johnston
Aug 1, 1978·American Journal of Obstetrics and Gynecology·M D CunninghamJ M Greene
Oct 1, 1967·The Biochemical Journal·C Prottey, J N Hawthorne
Mar 1, 1971·Journal of Applied Physiology·N S WangW M Thurlbeck
Jul 26, 1974·Biochimica Et Biophysica Acta·S A RooneyE K Motoyama
Jul 1, 1972·Chemistry and Physics of Lipids·R C PflegerJ Waide
May 1, 1961·Journal of Applied Physiology·J A CLEMENTSI GRIBETZ

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Citations

Jan 1, 1985·Molecular Aspects of Medicine·J L Harwood, R J Richards
Apr 1, 1984·Environmental Health Perspectives·S A Rooney
Apr 8, 1999·Progress in Lipid Research·J J Batenburg, H P Haagsman
Feb 7, 1983·Biochimica Et Biophysica Acta·P G HardingF Possmayer
Jan 1, 1987·Progress in Lipid Research·J L Harwood

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