Changes in descending motor pathway connectivity after corticospinal tract lesion in macaque monkey.

Brain : a Journal of Neurology
Boubker ZaaimiStuart N Baker

Abstract

Damage to the corticospinal tract is a leading cause of motor disability, for example in stroke or spinal cord injury. Some function usually recovers, but whether plasticity of undamaged ipsilaterally descending corticospinal axons and/or brainstem pathways such as the reticulospinal tract contributes to recovery is unknown. Here, we examined the connectivity in these pathways to motor neurons after recovery from corticospinal lesions. Extensive unilateral lesions of the medullary corticospinal fibres in the pyramidal tract were made in three adult macaque monkeys. After an initial contralateral flaccid paralysis, motor function rapidly recovered, after which all animals were capable of climbing and supporting their weight by gripping the cage bars with the contralesional hand. In one animal where experimental testing was carried out, there was (as expected) no recovery of fine independent finger movements. Around 6 months post-lesion, intracellular recordings were made from 167 motor neurons innervating hand and forearm muscles. Synaptic responses evoked by stimulating the unlesioned ipsilateral pyramidal tract and the medial longitudinal fasciculus were recorded and compared with control responses in 207 motor neurons from si...Continue Reading

References

Oct 24, 1975·Experimental Brain Research·B W PetersonR G Mackel
Mar 1, 1991·The Journal of Physiology·J Nielsen, E Pierrot-Deseilligny
Jan 14, 1972·Brain Research·M C Hepp-Reymond, M Wiesendanger
May 1, 1970·The Journal of Physiology·R Porter
Apr 1, 1982·Electroencephalography and Clinical Neurophysiology·C E Chapman, M Wiesendanger
May 1, 1993·Experimental Physiology·R N Lemon
Oct 6, 1997·Brain : a Journal of Neurology·J NetzV Hömberg
Dec 31, 1997·Stroke; a Journal of Cerebral Circulation·S C CramerB R Rosen
Mar 4, 2000·Stroke; a Journal of Cerebral Circulation·R S MarshallR L DeLaPaz
Mar 5, 2003·Brain : a Journal of Neurology·Dominique MazevetEmmanuel Pierrot-Deseilligny
May 24, 2003·Brain : a Journal of Neurology·N S WardR S J Frackowiak
Aug 26, 2003·Brain : a Journal of Neurology·N S WardR S J Frackowiak
Jan 1, 1955·Brain : a Journal of Neurology·P W NATHAN, M C SMITH
Dec 1, 1951·Brain : a Journal of Neurology·T E TWITCHELL
Feb 18, 2004·Nature Neuroscience·Florence M BareyreMartin E Schwab
Jun 4, 2004·Journal of Neurophysiology·Shigeto SasakiYukari Ohki
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jean-Alban Rathelot, Peter L Strick
Jul 13, 2007·The Journal of Comparative Neurology·Robert J MorecraftPreston Schneider
Jul 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam G DavidsonJohn A Buford
Jan 7, 2009·The Journal of Comparative Neurology·Ephron S RosenzweigMark H Tuszynski
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·C Nicholas RiddleStuart N Baker
Oct 15, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Yukio Nishimura, Tadashi Isa
Nov 16, 2010·Nature Neuroscience·Ephron S RosenzweigMark H Tuszynski
Jan 5, 2011·PloS One·Satoru Onodera, T Philip Hicks
Aug 5, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Demetris S SoteropoulosStuart N Baker
Sep 1, 2011·The Journal of Physiology·Stuart N Baker

❮ Previous
Next ❯

Citations

Jan 25, 2014·Lancet Neurology·Christian Grefkes, Gereon R Fink
Jun 6, 2013·Neural Plasticity·Lin JiangChunshui Yu
Jan 15, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Emilie GeorgeJeffrey Greenfield
Jul 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jacques Duysens
Jun 8, 2012·The Journal of Physiology·Karen M FisherStuart N Baker
May 30, 2012·The Journal of Physiology·Demetris S SoteropoulosStuart N Baker
Mar 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christopher CabibJosep Valls-Solé
Feb 27, 2016·Neurophysiologie clinique = Clinical neurophysiology·Melis SohtaoğluMelda Bozluolçay
Mar 24, 2016·Neural Plasticity·E B PlowA G Machado
Aug 21, 2015·Annals of Neurology·Wuwei FengGottfried Schlaug
Oct 31, 2015·PM & R : the Journal of Injury, Function, and Rehabilitation·Antonio CaronniGabriella Cerri
Jul 19, 2015·Behavioural Brain Research·Erhan GençOnur Güntürkün
Apr 14, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Volker Dietz, Miriam Schrafl-Altermatt
Mar 28, 2013·Annals of the New York Academy of Sciences·Marie-Claude Perreault, Joel C Glover
Apr 30, 2013·Muscle & Nerve·Allison S HyngstromSandra K Hunter
Aug 2, 2013·Acta Physiologica·C K ThomasI Zijdewind
Apr 8, 2015·Journal of Neurology·Neil G SimonMatthew C Kiernan
Feb 3, 2015·Annals of Clinical and Translational Neurology·Ander Ramos-MurguialdayNiels Birbaumer
Dec 24, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Meral E KiziltanGunes Kiziltan
Apr 20, 2016·Progress in Neurobiology·Yuan WangGuodong Cao
Apr 22, 2015·Neuron·Risa KawaiBence P Ölveczky
Mar 22, 2015·Experimental Brain Research·Leah R Enders, Na Jin Seo
Jul 6, 2014·Neuroscience·K A MoxonG Foffani
Jan 1, 2012·NeuroImage. Clinical·Holly E RossiterNick S Ward
Jan 17, 2014·NeuroImage. Clinical·Yohei TakenobuHidenao Fukuyama
Oct 2, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Raffaele NardoneEugen Trinka
Sep 10, 2013·Neuroscience Research·Tatsuya Umeda, Kengo Funakoshi
Apr 10, 2014·Brain : a Journal of Neurology·Claudia A AngeliSusan J Harkema
Apr 30, 2014·Frontiers in Neuroscience·Bror Alstermark, Lars-Gunnar Pettersson
Dec 30, 2014·Frontiers in Neurology·Gavin John ClowryFelix Chan
Jun 19, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Christian Grefkes, Nick S Ward

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.