Abstract
The effect of intracoronary nitroglycerin on coronary stenosis dimensions and translesional hemodynamics was evaluated in 38 subjects (74 stenoses) referred for diagnostic coronary arteriography. Quantitative coronary arteriography was performed with standard Newtonian fluid dynamic equations used to estimate transstenotic gradients. Since intracoronary nitroglycerin can induce significant myocardial hyperemia (increased flow velocity), with increased translesional pressure gradients and a decrease in distal intraluminal pressure, the potential effect on subendocardial flow distribution was also analyzed. Minimum stenotic diameter significantly increased postnitroglycerin (NTG) (preNTG 1.42 vs postNTG 1.82 mm, p less than 0.01), with a decrease in relative percent diameter stenosis (preNTG 45.7 vs postNTG 40.7%, p less than 0.05). When changes in minimum stenotic diameter were analyzed according to stenosis severity (quartiles), the greatest effect was noted in those lesions with the least severe stenosis (quartile no. 1, 0.49 vs quartile no. 4, 0.32 mm, p less than 0.05). If coronary blood flow velocity remains at baseline values (4 cm/s), intracoronary nitroglycerin was predicted to significantly decrease transstenotic pressu...Continue Reading
References
Nov 1, 1978·Circulation·J Mehta, C J Pepine
May 4, 1977·The American Journal of Cardiology·P F CohnJ Idoine
Aug 1, 1978·Circulation Research·K L Gould
Feb 1, 1977·Circulation·B G BrownH T Dodge
Jun 1, 1975·Circulation·K L GouldC Calvert
Jul 1, 1975·IEEE Transactions on Bio-medical Engineering·S E Logan
Feb 1, 1989·Journal of the American College of Cardiology·A E Moreyra, J B Kostis
May 1, 1986·Circulation·J E GageH P Krayenbuehl
May 1, 1986·American Heart Journal·M J KernR L Henry
Mar 25, 1988·The American Journal of Cardiology·K F Bachmann, R E Gansser
Nov 1, 1972·The Journal of Clinical Investigation·S F VatnerD Franklin
Apr 1, 1973·The Journal of Clinical Investigation·R FormanE H Sonnenblick
May 1, 1968·Circulation Research·W M Fam, M McGregor
Jan 1, 1971·Cardiovascular Research·P Mathes, J Rival
Jul 1, 1984·Circulation·B G BrownH T Dodge
Oct 1, 1981·Circulation Research·M MarcusM Brody
Dec 1, 1981·Circulation·B G BrownH T Dodge
Aug 1, 1982·Circulation·R L FeldmanC R Conti
May 1, 1980·British Heart Journal·W RafflenbeulT N James