Changes in diastolic time with various pharmacologic agents: implication for myocardial perfusion

Circulation
H BoudoulasA M Weissler

Abstract

Diastolic time (DT) is calculated as the cycle length (RR) minus electromechanical systole (QS2). The ratio of DT (RR-QS2) to RR interval times 100, or the percent diastole (%D), varies nonlinearly with heart rate (HR), increasing rapidly with decreasing HR. The effect of commonly used cardioactive agents on %D was studied in five groups of normal subjects. In group 1 (n = 12), propranolol (160 mg daily) increased %D from 55.9 +/- 1.7 to 64.7 +/- 1.3 (p less than 0.001) by slowing HR. In group 2 (n = 12), dobutamine (2.5 micrograms/kg/min) increased %D from 56.4 +/- 1.4 to 61.8 +/- 1.3 (p less than 0.005) by shortening the QS2. In group 3 (n = 10), Cedilanid-D (1.6 mg i.v.) increased %D from 55.5 +/- 1 to 63.2 +/- 0.7 (p less than 0.001), both by slowing the HR and shortening the QS2. In group 4 (n = 12), isoproterenol (2 micrograms/min) increased HR and shortened the QS2 significantly. The net result was a significant reduction of %D from 56.1 +/- 1.4 to 53.5 +/- 1.1, (p less than 0.05). In group 5 (n = 15), a 100-mg bolus of i.v. lidocaine did not have a significant effect on %D. This study indicates that cardiovascular drugs may have significant effects on the relative duration of diastole either by affecting HR or the durat...Continue Reading

References

Feb 1, 1978·The American Journal of Cardiology·J I Hoffman, G D Buckberg
Sep 1, 1978·The Annals of Thoracic Surgery·H BoudoulasJ S Vasko
Apr 1, 1976·The American Journal of Cardiology·R P LewisW F Forester
Apr 1, 1977·The American Journal of Cardiology·T A GillespieR Roberts
Nov 23, 1976·The American Journal of Cardiology·H K GoldP R Maroko
Sep 1, 1975·Progress in Cardiovascular Diseases·R Rubio, R M Berne
Jan 1, 1976·Circulation Research·D S Hess, R J Bache
Sep 1, 1974·Cardiovascular Research·B G BrownJ W Covell
Nov 1, 1974·Journal of Biomechanics·Y C PaoE H Wood
Jan 1, 1973·Advances in Experimental Medicine and Biology·D T Kelly, B Pitt
Jan 1, 1973·Advances in Experimental Medicine and Biology·G D Buckberg, A A Kattus
Mar 1, 1974·The American Journal of Physiology·R J Gordon
Jan 1, 1972·Circulation Research·G D BuckbergJ I Hoffman
Oct 1, 1972·The Journal of Clinical Investigation·S C SmithJ J Collins
Apr 1, 1970·Cardiovascular Research·B Pitt, P Craven
Oct 1, 1970·Cardiovascular Research·A J MossJ Sentman
Feb 1, 1968·Circulation·A M WeisslerC D Schoenfeld
Jan 1, 1966·Acta Anaesthesiologica Scandinavica. Supplementum·R L Katz, H Wang
Jan 1, 1964·Physiological Reviews·R M BERNE
Aug 1, 1964·The American Journal of Physiology·E S KIRK, C R HONIG
Sep 1, 1964·The American Journal of Physiology·E S KIRK, C R HONIG

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Citations

Apr 1, 1979·Clinical Cardiology·H BoudoulasJ S Vasko
Sep 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P LanzerG Pohost
Nov 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D E BohningG M Pohost
Jan 1, 1986·European Journal of Clinical Pharmacology·C D Burgess, J Crane
Jan 1, 1994·Journal of the American College of Cardiology·J C WynsenD C Warltier
Mar 15, 1996·Journal of the American College of Cardiology·H Boudoulas, C V Leier
Jan 1, 1999·Progress in Cardiovascular Diseases·C V Leier, P F Binkley
Jan 1, 1983·Journal of the American College of Cardiology·S B Knoebel
Oct 1, 1983·Journal of the American College of Cardiology·H BoudoulasC F Wooley
Jan 1, 1987·Journal of the American College of Cardiology·H BoudoulasC F Wooley
Jan 1, 1994·British Journal of Pharmacology·C D Drieu la RochelleS E O'Connor
Nov 16, 2010·Cardiovascular Ultrasound·Tonino BombardiniEugenio Picano
May 23, 2006·AJR. American Journal of Roentgenology·Harpreet K PannuElliot K Fishman
Oct 23, 2010·AJR. American Journal of Roentgenology·Hidenari MatsumotoYuji Hiraoka
Apr 28, 2005·AJR. American Journal of Roentgenology·Leo P LawlerElliot K Fishman
Mar 31, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Tadashi NakanishiYukihiko Gomyo
Oct 15, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Harpreet K PannuElliot K Fishman
Feb 15, 2008·Medical & Biological Engineering & Computing·Jeroen P H M van den WijngaardJos A E Spaan
Nov 20, 2004·Radiology·Martin H K HoffmannAndrik J Aschoff
Aug 31, 2000·Coronary Artery Disease·S R PatelA P Levy
Jan 20, 2011·Acute Cardiac Care·Shadi Karebsheh, Andrew D Michaels
Jan 16, 2016·Current Cardiology Reports·Mateo Porres-AguilarAamer Abbas

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