Changes in distribution spaces and cell permeability caused by ATP in the rat liver

Liver
T R L FernandesA Bracht

Abstract

Cellular and extracellular volume changes caused by ATP were investigated in the liver as well as the possible formation of diffusion barriers, which could be responsible for some of its metabolic effects. The experimental system was the bivascularly perfused rat liver. [(14)C]Sucrose and [(3)H]water were simultaneously injected into either the portal vein or the hepatic artery. Mean transit times, distribution spaces, variances and linear superimpositions were calculated. In the portal system, ATP reduced the transit time in the great vessels, had little or no effect on sinusoidal and cellular spaces, but impaired the flow-limited distribution of both [(14)C]sucrose and [(3)H]water. In the arterial bed ATP infused into either the portal vein or the hepatic artery produced vasodilation and increased the aqueous extra-sucrose space. These effects were inhibited by Nomega-nitro-L-arginine methyl ester infused into the hepatic artery. Sucrose and extra-sucrose space changes caused in the arterial bed by portally infused ATP are most probably analogous to the transhepatic vasodilation effect already described for the rabbit liver. Impairment of flow-limited distribution of tracers in the sinusoidal bed indicates that ATP induces th...Continue Reading

References

Feb 19, 1992·Biochimica Et Biophysica Acta·C el-MoatassimJ C Mani
Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I KassissiaS Guirguis
Jun 12, 1992·Biochimica Et Biophysica Acta·F Suzuki-KemmelmeierA Bracht
Nov 15, 1991·The Biochemical Journal·S vom DahlD Häussinger
May 1, 1991·British Journal of Pharmacology·V RalevicG Burnstock
Jun 1, 1991·British Journal of Pharmacology·R T MathieG Burnstock
Jan 1, 1985·General Pharmacology·G Burnstock, C Kennedy
Aug 1, 1986·The Biochemical Journal·D B BuxtonM S Olson
Dec 15, 1987·European Journal of Biochemistry·D HäussingerK Decker
Nov 1, 1970·Circulation Research·C A GoreskyG G Bach
Sep 1, 1993·The American Journal of Physiology·G R Dubyak, C el-Moatassim
Jan 7, 1997·Journal of Theoretical Biology·M Weiss
Jun 6, 1998·Molecular and Cellular Biochemistry·V C Minguetti-CâmaraA Bracht
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·E ClementiS Moncada
Jul 29, 1999·Biochemical Pharmacology·T R FernandesA Bracht
Jun 1, 1954·Journal of Applied Physiology·P MEIER, K L ZIERLER
Apr 1, 1963·The American Journal of Physiology·C A GORESKY
Oct 1, 1964·The American Journal of Physiology·C A GORESKY, M SILVERMAN

❮ Previous
Next ❯

Citations

May 10, 2005·Regulatory Peptides·Angelita Polato SchmeischAdelar Bracht
Nov 8, 2002·European Journal of Pharmacology·Talma R L FernandesAdelar Bracht
Jan 9, 2010·Journal of Biomedical Science·Jurandir F ComarAdelar Bracht
Nov 11, 2008·Chemico-biological Interactions·Carlos Henrique LopezAdelar Bracht
Jan 8, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Talma R L FernandesAdelar Bracht
May 28, 2005·Cell Biochemistry and Function·Daniele GimenesAdelar Bracht
May 5, 2012·Journal of Gastroenterology and Hepatology·Mathilde SteenksGreg J Barritt
Aug 11, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jurandir Fernando ComarAdelar Bracht

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Liver International : Official Journal of the International Association for the Study of the Liver
T R L FernandesA Bracht
Liver International : Official Journal of the International Association for the Study of the Liver
Fernanda Fonseca BotiniA Bracht
Biochimica Et Biophysica Acta
F Suzuki-KemmelmeierA Bracht
© 2022 Meta ULC. All rights reserved