PMID: 9185673May 23, 1997Paper

Changes in dopamine and acetylcholine release in the rat lateral hypothalamus during deprivation-induced drinking

Neuroscience Letters
M Puig de ParadaQ Contreras

Abstract

Neurochemical changes in the rat lateral hypothalamus during drinking were assessed in 20 min sampling intervals, using in vivo brain microdialysis. Water-deprived animals drank (11 +/- 1 ml) during the hour that water was available. Drinking was maximal (7.8 +/- 0.7 ml) during the first 20 min after water presentation and minimal during the last 20 min (0.5 +/- 0.4 ml). There was a local enhancement in DA turnover evidenced by an increase in the extracellular levels of dopamine (DA) (155 +/- 47% during the second sample after water presentation as compared to predrinking levels) and dihydroxyphenyl acetic acid (DOPAC) (132 +/- 9.7% in the sample that followed water removal). There was also an initial increase in the acetylcholine (ACh) release (145.1 +/- 21.7%) during the first 20 min after water presentation followed by a reduction (50.12 +/- 18%) 20 min later. These changes are congruous with previously published results suggesting that both neurochemical systems are involved in the regulation of water intake. Considering that the exogenous administration of cholinergic drugs in this hypothalamic area elicits drinking, the initial increase in ACh release could be interpreted as one of the neurochemical events driving this be...Continue Reading

References

Jul 1, 1990·Brain Research Bulletin·M FukudaR Tamura
Dec 29, 1986·Life Sciences·L HernandezB G Hoebel
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Citations

Oct 2, 2003·European Journal of Pharmacology·Shahrbanoo OryanBehrooz Kohanrooz
Jul 6, 2000·Pharmacology, Biochemistry, and Behavior·M P De ParadaB G Hoebel
Feb 9, 2011·Behavioural Brain Research·Gertjan van DijkCsaba Nyakas
Jul 20, 2006·Genes, Brain, and Behavior·R M CostaS A Simon
Jan 15, 2005·Biochemical and Biophysical Research Communications·W Almaguer-MelianJ Bergado
Nov 12, 2003·Nutritional Neuroscience·J Ernie BlevinsDorothy W Gietzen
Feb 13, 2001·Methods : a Companion to Methods in Enzymology·J C DayR Quirion

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