Changes in Dopamine Transmission in the Nucleus Accumbens Shell and Core during Ethanol and Sucrose Self-Administration

Frontiers in Behavioral Neuroscience
Valentina BassareoGaetano Di Chiara

Abstract

Ethanol, like other substances of abuse, preferentially increases dopamine (DA) transmission in the rat nucleus accumbens (NAc) following passive administration. It remains unclear, however, whether ethanol also increases NAc DA transmission following operant oral self-administration (SA). The NAc is made-up of a ventro-medial compartment, the shell and a dorso-lateral one, the core, where DA transmission responds differentially following exposure to drugs of abuse. Previous studies from our laboratory investigated changes in dialysate DA in the NAc shell and core of rats responding for sucrose pellets and for drugs of abuse. As a follow up to these studies, we recently investigated the changes in NAc shell and core DA transmission associated to oral SA of a 10% ethanol solution. For the purpose of comparison with literature studies utilizing sucrose + ethanol solutions, we also investigated the changes in dialysate DA associated to SA of 20% sucrose and 10% ethanol + 20% sucrose solutions. Rats were trained to acquire oral SA of the solutions under a Fixed Ratio 1 (FR1) schedule of nose-poking. After training, rats were monitored by microdialysis on three consecutive days under response contingent (active), reward omission (ex...Continue Reading

References

Sep 10, 1985·European Journal of Pharmacology·G Di Chiara, A Imperato
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·F E PontieriG Di Chiara
Mar 14, 1997·Science·W SchultzP R Montague
Apr 26, 2003·The European Journal of Neuroscience·Valentina BassareoGaetano Di Chiara
Jul 25, 2003·Alcoholism, Clinical and Experimental Research·Amanda TangRueben A Gonzales
Oct 24, 2003·Alcoholism, Clinical and Experimental Research·William M DoyonRueben A Gonzales
Sep 17, 2004·Pharmacology & Therapeutics·Rueben A GonzalesWilliam M Doyon
Aug 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brandon J AragonaR Mark Wightman
Dec 3, 2008·The European Journal of Neuroscience·Nadia ChaudhriPatricia H Janak
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Frederic AmbroggiHoward L Fields

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Citations

Jan 23, 2020·Journal of Psychopharmacology·Cristiane A FavorettoIsabel M Hartmann Quadros
Oct 3, 2018·Frontiers in Behavioral Neuroscience·Herbert E CovingtonKlaus A Miczek
Mar 27, 2020·Frontiers in Behavioral Neuroscience·Priscila Fernandes Carrara-NascimentoRosana Camarini
Nov 2, 2019·Neuroscience and Biobehavioral Reviews·Roberto U CofresíThomas M Piasecki
Dec 31, 2017·Neuroscience Letters·Jana Ruda-KucerovaYousef Tizabi
Oct 26, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Abdelkader Dahchour, Roberta J Ward

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