Changes in EEG complexity with electroconvulsive therapy in a patient with autism spectrum disorders: a multiscale entropy approach

Frontiers in Human Neuroscience
Ryoko OkazakiYuji Wada

Abstract

Autism spectrum disorders (ASD) are heterogeneous neurodevelopmental disorders that are reportedly characterized by aberrant neural networks. Recently developed multiscale entropy analysis (MSE) can characterize the complexity inherent in electroencephalography (EEG) dynamics over multiple temporal scales in the dynamics of neural networks. We encountered an 18-year-old man with ASD whose refractory catatonic obsessive-compulsive symptoms were improved dramatically after electroconvulsive therapy (ECT). In this clinical case study, we strove to clarify the neurophysiological mechanism of ECT in ASD by assessing EEG complexity using MSE. Along with ECT, the frontocentral region showed decreased EEG complexity at higher temporal scales, whereas the occipital region expressed an increase at lower temporal scales. Furthermore, these changes were associated with clinical improvement associated with the elevation of brain-derived neurotrophic factor, which is a molecular hypothesis of ECT, playing key roles in ASD pathogenesis. Changes in EEG complexity in a region-specific and temporal scale-specific manner that we found might reflect atypical EEG dynamics in ASD. Although MSE is not a direct approach to measuring neural connectivit...Continue Reading

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Citations

Feb 10, 2016·Human Brain Mapping·Tetsuya TakahashiMitsuru Kikuchi
Feb 24, 2016·Drug Development Research·Walter H MoosKosta Steliou
Dec 14, 2018·Frontiers in Neuroscience·Intan LowLi-Fen Chen
Oct 31, 2018·International Journal of Neural Systems·Arturo Martínez-RodrigoAntonio Fernández-Caballero
Jun 12, 2020·Physical and Engineering Sciences in Medicine·Maryam RezaeezadehMousa Shamsi
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Jul 20, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jiannan KangXiaoli Li
Oct 14, 2021·Scientific Reports·Kelly ShenAnthony R McIntosh

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Software Mentioned

Mathematica
Brain Vision Analyzer

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