PMID: 8594943Dec 1, 1995Paper

Changes in efferent pulmonary sympathetic nerve activity during systemic hypoxia in anesthetized cats

The American Journal of Physiology
M ShiraiI Ninomiya

Abstract

Changes in efferent sympathetic nerve activity to the pulmonary vessels during systemic hypoxia have yet to be elucidated. The purpose of this study was to determine the pulmonary sympathetic nerve activity (PSNA) changes in response to acute systemic hypoxia before and after sinoaortic denervation plus vagotomy in anesthetized cats. The denervation was performed to estimate the central nervous system-mediated peripheral chemoreceptor- and baroreceptor-independent PSNA change. PSNA was recorded from the central end of the cut nerve bundle, which was isolated from the lobar artery supplying the diaphragmatic lobe. Renal sympathetic nerve activity (RSNA) and systemic and pulmonary arterial pressures were also measured simultaneously. The animals were submitted to approximately 3-min periods of graded hypoxia (16, 12, 8, 5, and 3% O2 inhalations). PSNA did not change from normoxia down to an arterial O2 partial pressure (PaO2) of approximately 45 Torr (with 12-21% O2 inhalations). Below this level, PSNA began to increase, and markedly so (approximately 2.5-fold) at a PaO2 of approximately 15 Torr (with 3% O2). The hypoxic PSNA increase was significantly larger than that for RSNA, with a PaO2 of less than approximately 30 Torr (wit...Continue Reading

Citations

Jun 19, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Satoshi KobaJianhua Li
Mar 10, 2000·Journal of Applied Physiology·H SchneiderC P O'Donnell
May 27, 2006·Journal of Applied Physiology·Brendan J Canning
Aug 29, 2019·International Journal of Environmental Research and Public Health·Hiroshi KimuraShin Takasawa
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S F Morrison
Oct 14, 2006·Journal of Applied Physiology·Daryl O SchwenkeMikiyasu Shirai
Mar 24, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C DiongD O Schwenke
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward

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