Changes in end-tidal carbon dioxide tension following sodium bicarbonate administration: correlation with cardiac output and haemoglobin concentration

Acta Anaesthesiologica Scandinavica
H OkamotoS Takahashi

Abstract

An intravenous administration of sodium bicarbonate (NaHCO3) forms excess CO2, resulting in an immediate increase in end-tidal carbon dioxide tension (PETCO2). We hypothesized that the time until PETCO2 reached a maximum, and the magnitude of the increase in PETCO2 are influenced by cardiac output and haemoglobin concentration, respectively. To test this hypothesis, we examined changes in PETCO2 following an intravenous administration of NaHCO3 at different levels of cardiac output and haemoglobin concentration. We administered 0.2 mmol.kg-1 of 8.4% NaHCO3 into the vena cava in 15 anesthetized dogs under mechanical ventilation of 20 breaths per min. Cardiac output was increased by dopamine infusion, and decreased by blood withdrawal under halothane anaesthesia. Haemoglobin concentrations were changed by haemodilution with hydroxyethyl starch. When control measurements were taken, time-max (the time until the increase in PETCO2 reached a maximum) was 4 +/- 0.2 breaths-time, and delta CO2-max (the magnitude of the increase in PETCO2) was 0.90 +/- 0.04 kPa (6.6 +/- 0.3 mmHg). Cardiac output was inversely correlated with time-max (r = 0.94, P < 0.0001), while it revealed a poor correlation with delta CO2-max. Haemoglobin concentrat...Continue Reading

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Citations

Jul 11, 1998·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·K R Ward, D M Yealy
May 17, 2011·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Sharon EinavIdit Matot
Jul 8, 2015·Heart, Lung & Circulation·Charalampos PantazopoulosNicoletta Iacovidou
May 6, 2015·The American Journal of Emergency Medicine·Mu Jin KimYong Il Min
Sep 17, 2011·Revista brasileira de anestesiologia·Luiz Fernando dos Reis FalcãoJosé Luiz Gomes do Amaral
Sep 18, 2016·The American Journal of Emergency Medicine·An-Yi WangWen-Jone Chen
Aug 5, 2017·Antiviral Chemistry & Chemotherapy·Angel S GalabovDorotea Sidzhakova
Jun 7, 2011·Anesthesia and Analgesia·Ilan KeidanHaim Berkenstadt
May 16, 2012·Anesthesia and Analgesia·Ilan KeidanHaim Berkenstadt
Sep 29, 2020·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Michael W HubbleGinny K Renkiewicz
Oct 2, 2020·Journal of the American College of Emergency Physicians Open·Matthew R NethMohamud R Daya
Feb 16, 2021·Frontiers in Veterinary Science·Daniel J Fletcher, Manuel Boller
Oct 2, 2020·Current Opinion in Critical Care·Tonia C Nicholson, Edison F Paiva

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