PMID: 3771376Jan 1, 1986Paper

Changes in endolymph chloride concentration following furosemide injection

Hearing Research
L P Rybak, C Whitworth

Abstract

Endocochlear potential (EP) and chloride concentration in endolymph were monitored with microelectrodes in the basal turn of the cochlea of the chinchilla. After intravenous injection of furosemide (25-100 mg/kg), the EP dropped precipitously and rapidly reached its minimum value, however, the chloride activity in endolymph decreased more gradually. Possible mechanisms for this phenomenon include a reduced electrostatic attraction of chloride ions to the scala media due to a decreased EP and a reduction of passive influx of chloride into endolymph, resulting from a reduction of active inward potassium transport by furosemide.

References

May 1, 1979·Acta Oto-laryngologica·T Konishi
Jan 1, 1975·Progress in Neurobiology·P M Sellick, B M Johnstone
Sep 1, 1985·The Laryngoscope·L P Rybak
Jul 1, 1982·Hearing Research·L P Rybak, T Morizono
Jul 1, 1983·Journal of Neuroscience Methods·J L MunozJ A Coles
Nov 1, 1982·American Journal of Otolaryngology·T Konishi
Mar 1, 1983·Pflügers Archiv : European journal of physiology·R Greger, E Schlatter

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Citations

Feb 1, 1995·Hearing Research·K E RareyW J ten Cate
May 1, 1997·Hearing Research·K IkedaT Takasaka
Apr 3, 2004·The Journal of the Acoustical Society of America·Davud B SirjaniShane A Hale
Jan 24, 2004·The Tohoku Journal of Experimental Medicine·Katsuhisa Ikeda
Apr 8, 2017·Scientific Reports·Min Young LeeYehoash Raphael
Jun 30, 2018·Physiological Genomics·Janet L Fitzakerley, George J Trachte

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