Changes in endometrial transcription of TLR2, TLR4, and CD14 during the first-week postpartum in dairy cows with retained placenta

Theriogenology
Telma da Mata MartinsÁlan Maia Borges

Abstract

Changes in the endometrial transcription of pattern recognition receptors may increase the susceptibility to postpartum uterine infections in Holstein cows with retained placenta. To test this hypothesis, nine cows with retained placenta and ten cows without retained placenta were submitted to endometrial biopsies at the first and seventh days postpartum. Cows were monitored weekly with clinical and gynecological examinations until 42 days postpartum. Samples of the uterine contents were collected weekly for aerobic bacteria isolation. All cows had endometrial transcription of Toll-like receptors (TLRs) 1/6, 2, 4, 5, and 9; nucleotide-binding oligomerization domain (NOD)-like receptors 1 and 2; and the coreceptors cluster of differentiation 14 (CD14) and myeloid differentiation protein-2 (MD-2), as measured on the first and seventh days postpartum. Escherichia coli was the most common bacterium isolated from the uterine contents of cows with or without retained placenta until 21 days postpartum. Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased (P < 0.05) between the first and the seventh day postpartum. Conversely, cows without retained placenta did not have any signif...Continue Reading

References

Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N Kobayashi, K McEntee
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Jun 8, 2002·Reproduction : the Official Journal of the Society for the Study of Fertility·I M SheldonH Dobson
Jun 20, 2002·Trends in Immunology·Martha Triantafilou, Kathy Triantafilou
Jan 1, 2003·Veterinary Immunology and Immunopathology·Dirk Werling, Thomas W Jungi
Sep 24, 2005·Nature Immunology·Frederick M Ausubel
Oct 18, 2005·Theriogenology·I Martin SheldonRobert O Gilbert
Jun 3, 2006·Veterinary Immunology and Immunopathology·D S HammonJ L Walters
Sep 7, 2006·Journal of Endotoxin Research·Kensuke Miyake
Sep 18, 2007·Theriogenology·M J Bell, D J Roberts
May 20, 2008·Current Opinion in Pharmacology·Svend T RietdijkAnthony J Coyle
May 30, 2009·Reproductive Biology and Endocrinology : RB&E·Shan HerathI Martin Sheldon
Mar 9, 2010·Theriogenology·Timothy J PotterI Martin Sheldon
Mar 23, 2010·Cell·Osamu Takeuchi, Shizuo Akira
Nov 12, 2010·Veterinary Immunology and Immunopathology·Telma da Mata MartinsÁlan Maia Borges
Nov 23, 2010·Nature Reviews. Immunology·Grace Y Chen, Gabriel Nuñez
Apr 19, 2011·Animal Reproduction Science·T R KannakiP C Verma
Dec 14, 2011·Veterinary Immunology and Immunopathology·Ana Patrícia Carvalho SilvaRenato Lima Santos
Oct 19, 2012·Biology of Reproduction·Theerawat Swangchan-UthaiD Claire Wathes

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.