Changes in endothelium-dependent arterial dilation before and after subtotal thyroidectomy in subjects with hyperthyroidism

Clinical Endocrinology
Xiang Guang-daZeng Xian-mei

Abstract

This case-control study was carried out to assess the alteration of endothelium-dependent arterial dilation before and after subtotal thyroidectomy in subjects with hyperthyroidism. The study subjects included 12 patients with hyperthyroidism and 39 apparently healthy individuals. We performed a subtotal thyroidectomy on the hyperthyroid patients. The endothelium-dependent arterial dilation was determined with a high-resolution ultrasound method in each patient at the hyperthyroid stage before treatment (stage H), the euthyroid stage induced immediately before surgery (stage E), and the transient hypothyroid stage 1 or 2 months after surgery (stage L). The flow-mediated arterial dilation decreased significantly from H to E and from E to L (P < 0.001). As compared with H, baseline blood flow decreased markedly at stages E and L (P < 0.001). The flow-mediated arterial dilation and baseline blood flow in the control subjects were very close to those at stage E of the hyperthyroid patients. The absolute change in the flow-mediated arterial dilation showed significant negative correlation with the changes in TSH (r =-0.86, P < 0.001), lipoprotein (a) [Lp(a)] (r =-0.77, P < 0.001) and low density lipoprotein (LDL) (r =-0.79, P < 0.00...Continue Reading

References

Jan 1, 1995·Metabolism: Clinical and Experimental·K YamamotoT Sakai
May 1, 1993·Circulation·R PolikarP Nicod
Oct 1, 1996·Thyroid : Official Journal of the American Thyroid Association·K OjamaaI Klein
Mar 7, 1998·American Heart Journal·M Gomberg-Maitland, W H Frishman
Feb 15, 2001·The New England Journal of Medicine·I Klein, K Ojamaa
Jun 28, 2003·Cardiovascular Research·E BüssemakerR P Brandes
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·Stefano TaddeiFabio Monzani

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Citations

Jul 7, 2007·Thyroid : Official Journal of the American Thyroid Association·Penelope J D OwenJohn H Lazarus
Nov 18, 2008·European Heart Journal·Henry VölzkeMarcus Dörr
Jul 27, 2011·Journal of Lipids·Melpomeni PeppaGeorge Dimitriadis
Oct 28, 2009·Vascular Pharmacology·Maria Luiza M Barreto-ChavesGabriela P Diniz
Jul 20, 2007·Clinical Endocrinology·Wan-Jing HoWei-Jan Chen
Dec 31, 2020·The Journal of Clinical Hypertension·Stanislovas S JankauskasGaetano Santulli

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