Changes in endotoxin-induced cytokine production by whole blood after in vivo exposure of normal humans to endotoxin

The Journal of Infectious Diseases
T van der PollS F Lowry

Abstract

Whole blood of 6 healthy subjects, who were intravenously injected with lipopolysaccharide (LPS, 2 ng/kg), was stimulated ex vivo with LPS (10 ng/mL). Three and 6 h after injection of LPS, whole blood produced less tumor necrosis factor-alpha (TNF), interleukin (IL)-1beta, IL-6, and IL-10 (all P < .05). By contrast, the production of IL-1 receptor antagonist was enhanced after LPS injection (P < .05). Plasma obtained 2 h, but not 1 h, after in vivo administration of LPS showed a dose-dependent inhibition of TNF, IL-1beta, and IL-6 production by LPS-stimulated whole blood from 6 other healthy donors not previously exposed to LPS, while the production of IL-10 and IL-1 receptor antagonist were not or were marginally influenced. LPS tolerance represents a purposeful adaptation of the host, rather than a generalized hyporesponsiveness, and is at least partly mediated by soluble factors produced within 2 h after previous exposure to LPS.

Citations

May 26, 1999·Infectious Disease Clinics of North America·T van der Poll, S J van Deventer
Dec 24, 2002·Journal of the American College of Surgeons·Scott R SchellEdward M Copeland
Jul 14, 2007·Nature Reviews. Immunology·Adrian E Morelli, Angus W Thomson
Jan 26, 1999·Annals of the New York Academy of Sciences·E Zeisberger, J Roth
Aug 25, 2010·Journal of Innate Immunity·Charles E McCallMohamed El Gazzar
Jan 27, 2007·American Journal of Respiratory and Critical Care Medicine·Charles E McCall, Barbara K Yoza
Oct 21, 2010·American Journal of Respiratory and Critical Care Medicine·Jacobien J HoogerwerfTom van der Poll
May 19, 2009·American Journal of Respiratory Cell and Molecular Biology·Jacobien J HoogerwerfTom van der Poll
Aug 26, 2014·Research in Veterinary Science·Chiara BernardiniMonica Forni
Aug 13, 2008·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Angelique L Veenstra van NieuwenhovenMarijke M Faas
Feb 18, 2010·Computers & Chemical Engineering·P T FoteinouI P Androulakis
Oct 3, 1998·Gastroenterology·J J Spitzer, A P Bautista
Apr 25, 2003·American Journal of Obstetrics and Gynecology·Angelique L Veenstra van NieuwenhovenMarijke M Faas
Nov 11, 2003·Journal of the American College of Cardiology·Johannes PleinerMichael Wolzt
Aug 24, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M L FernandesR Salomão
Feb 5, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Mahmoud SadeghiGerhard Opelz
Dec 20, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·G MüllerH Köhler
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Philip LakeDean Handley
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alex F de VosTom van der Poll
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cornelis van 't VeerTom van der Poll
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D G PerregauxC A Gabel
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean HuLiwu Li
Apr 2, 2020·BMC Neurology·Zunera ZareenEleanor J Molloy
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A VerbonT van der Poll
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria WysockaChristopher L Karp
Sep 21, 2018·Frontiers in Immunology·Annemieke M Peters van TonPeter Pickkers
Jun 2, 2020·Frontiers in Immunology·Xanthe BrandsTom van der Poll
Nov 14, 2020·Developmental Medicine and Child Neurology·Zunera ZareenEleanor J Molloy
Dec 6, 2001·Experimental and Molecular Pathology·G K YadavalliF P Heinzel
Aug 18, 2021·Journal of Pharmacological and Toxicological Methods·Yevgeniya E KoshmanBruce E LeRoy

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