PMID: 9552578Jan 1, 1996Paper

Changes in energy metabolism of calf muscle in patients with intermittent claudication assessed by 31P magnetic resonance spectroscopy: a phase II open study

Vascular Medicine
D J TaylorG K Radda

Abstract

Energy status and metabolism in skeletal muscle of nine patients with peripheral arterial disease and suffering from intermittent claudication were evaluated using 31phosphorus magnetic resonance spectroscopy (MRS) before and after treatment for 3 months with propionyl-L-carnitine (PLC; 2 g/day p.o.). Maximum walking distance (MWD) was assessed on a standard treadmill (4 km/h, zero incline). For the group as a whole 31P MRS results did not change significantly with PLC. Although MWD increased by a mean of 36%, this change did not reach significance. However, when these variables were assessed with respect to the change in MWD, there were significant differences between those who increased MWD by > 30% (responders, R; n = 5) and those who did not (nonresponders, NR; n = 4). Compared with pretreatment values, during exercise the decrease in muscle pH in R relative to the decrease in phosphocreatine was less after PLC (p = 0.04). After exercise there was a significant inverse correlation between the changes in recovery half-time (t1/2) for phosphocreatine and in MWD (r = -0.91, p = 0.01). With PLC, Vmax increased in R (p = 0.04), but not in NR. For the patient group as a whole, the changes in Vmax and MWD correlated positively (r ...Continue Reading

References

Nov 15, 1981·The Biochemical Journal·A C Bylund-FelleniusT Scherstén
Nov 15, 1995·Journal of the American College of Cardiology·G BrevettiM Condorelli
Dec 20, 1994·Journal of the Neurological Sciences·D J TaylorG K Radda

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Citations

Dec 14, 2004·Annals of the New York Academy of Sciences·William R Hiatt
Dec 14, 2004·Annals of the New York Academy of Sciences·Roberto FerrariC Ceconi
Oct 16, 2009·Expert Opinion on Pharmacotherapy·G M Andreozzi
Apr 28, 2011·Nutrition Reviews·Carmen MingoranceMaria Alvarez de Sotomayor
Apr 16, 2003·The Medical Clinics of North America·R FerrariG Guardigli
Aug 22, 2017·Journal of Vascular Surgery·Amy E HarwoodIan C Chetter

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