PMID: 7540053Apr 1, 1995Paper

Changes in epidermal growth factor receptor and the levels of its ligands during menstrual cycle in human endometrium

Biology of Reproduction
T ImaiM Sakata

Abstract

We examined menstrual cycle-dependent changes in the expression of human endometrial epidermal growth factor (EGF), transforming growth factor alpha (TGF alpha), and epidermal growth factor receptor (EGFR) and their mRNA using immunoblot analysis, 125I-EGF binding, and competitive reverse transcription and polymerase chain reaction (RT-PCR). We also studied their localization in the endometrial tissue by immunohistochemistry. Endometrial samples were obtained at three stages of menstruation: the early follicular stage, which exhibits low serum estradiol (E2) and progesterone (P) levels; the late follicular stage, which exhibits high E2 and low P levels; and the luteal stage, which exhibits high E2 and P levels. Immunohistochemical examination showed that EGF, TGF alpha, and EGFR were localized to the endometrial epithelium. Immunoblot analysis revealed that endometrial EGF, TGF alpha, and EGFR levels were significantly (p < 0.01) increased at the late follicular and luteal stages compared to the early follicular stage. 125I-EGF-specific binding levels at the late follicular and luteal stages were significantly (p < 0.01) higher than at the early follicular stage, consistent with the results of immunoblot analysis. Competitive R...Continue Reading

Citations

Jun 16, 1999·Molecular Reproduction and Development·C GerstenbergF Stewart
Jan 5, 2000·Molecular Reproduction and Development·Z P YueM J Harper
Oct 13, 2007·Journal of Molecular Histology·Seppo Edvin Partanen
Apr 13, 2002·Annals of the New York Academy of Sciences·Robert N TaylorMichael D Mueller
Nov 11, 2010·Reproductive Sciences·Lusine Aghajanova, Linda C Giudice
Nov 25, 2004·The Journal of Clinical Endocrinology and Metabolism·Katya ChobotovaHelen J Mardon
Oct 6, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T TanakaS Ogita
May 1, 2001·Seminars in Pediatric Surgery·D P O'BrienB W Warner
Feb 9, 2011·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·H SağsözB G Saruhan
Dec 8, 2015·Reproduction in Domestic Animals = Zuchthygiene·A L SaraivaM A Pires
Nov 17, 2007·Cancer Letters·Giannoula SouflaDemetrios A Spandidos
Nov 27, 2015·Biological Reviews of the Cambridge Philosophical Society·Eline WydoogheAnn Van Soom
Sep 11, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ziming Yu, Dinesh M Shah
Nov 5, 2010·The American Journal of Pathology·Hellen DassenAndrea Romano
Mar 11, 2015·Veterinary Research Communications·Emel AlanHakan Sağsöz
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·C SimónA Pellicer
Oct 27, 1999·The Journal of Surgical Research·R A FalconeB W Warner
Oct 27, 2004·Molecular Human Reproduction·Anna P PonnampalamPeter A W Rogers
Jul 13, 2006·Human Reproduction Update·Thomas StrowitzkiM von Wolff
Apr 20, 2016·Oncotarget·Brian J EngelDaniel D Carson
Aug 16, 2005·Molecular Human Reproduction·Kirsten EjskjaerE Nexø
Oct 12, 2001·Annals of the New York Academy of Sciences·C J LockwoodF Schatz
Apr 3, 1999·The Journal of Biological Chemistry·B K PilcherH G Welgus
Jan 17, 2009·Reproductive Biomedicine Online·C M BoomsmaN S Macklon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.