Changes in epidermal proliferation and differentiation in allergic and irritant contact dermatitis reactions

The British Journal of Dermatology
T K LeP C van de Kerkhof

Abstract

Allergic and irritant contact dermatitis are similar clinically, histologically and on immunohistochemistry. In the present investigation, we assessed whether study of the recruitment of cycling epidermal cells, and the expression of keratin 16 and involucrin, are of use in differentiating between the response to contact allergens and the response to the irritant detergent sodium lauryl sulphate. Both allergic and irritant challenges induced epidermal proliferation, and the expression of keratin 16 and involucrin, but the dynamics were different. Two and 3 days after challenge, a highly significant difference between the allergic and irritant reactions was observed with respect to involucrin expression assessed by MON-150 staining.

References

Sep 1, 1992·Clinical and Experimental Dermatology·P H van der SteenP C van de Kerkhof
Feb 1, 1992·The Journal of Investigative Dermatology·J BraschW Sterry
Jan 1, 1992·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·A J de ZwartP C van de Kerkhof
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Jan 1, 1990·Archives of Dermatological Research·S de MareP C van de Kerkhof
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Oct 1, 1987·The British Journal of Dermatology·J KanitakisJ Thivolet
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Mar 1, 1995·Clinics in Dermatology·F Van RuissenJ Schalkwijk

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Citations

Jul 1, 1997·Clinics in Dermatology·E Berardesca
Jan 5, 1999·Contact Dermatitis·T PetersK Scharffetter-Kochanek
Jan 21, 2004·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Anthony Teik-Jin GoonChee-Leok Goh
Dec 8, 2006·Dermatitis : Contact, Atopic, Occupational, Drug·Susanne AstnerErnesto Gonzalez
Jul 1, 1996·Contact Dermatitis·M A Fung, H I Maibach
Jan 22, 2003·The British Journal of Dermatology·K FriebeH Löffler
Sep 18, 1998·The Journal of Investigative Dermatology·S Ekanayake-MudiyanselageE Proksch

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