PMID: 7537524Mar 1, 1995Paper

Changes in erythroid progenitor cell and accessory cell compartments in patients with myelodysplastic syndromes during treatment with all-trans retinoic acid and haemopoietic growth factors

British Journal of Haematology
A MaurerD Hoelzer

Abstract

Differentiation induction therapy is used in myelodysplastic syndromes (MDS) to improve maturation defects and to restore impaired function of malignant cells. To this end, 18 patients with MDS received either a combination therapy consisting in study 1 of all-trans retinoic acid (ATRA) and granulocyte-colony stimulating factor (G-CSF), or in study 2 of a combination with ATRA, G-CSF, erythropoietin (Epo) and tocopherol. The ANC increased in 19/20 patients in both studies, whereas an increase in haemoglobin concentration, platelet counts or reduction of transfusion requirement was seen in only 8/20 patients, correlating strongly with good BFU-E growth (P < 0.001). To assess the role of accessory cells in the modulation of the haemopoietic response to treatment, we analysed the capacity of peripheral blood monocytes to secrete cytokines (IL-1 beta, IL-6, IL-8, TNF alpha). Secretion of all cytokines was significantly reduced before therapy when compared with healthy controls, but increased during therapy, reaching normal levels for IL-8. These data indicate that a combination therapy with ATRA and cytokines improves impaired cytokine secretion from monocytes and induces a multilineage clinical response in a subgroup of MDS patien...Continue Reading

References

Jul 1, 1992·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W Bollag, E E Holdener
Jul 1, 1992·The Journal of Experimental Medicine·A GarbeU Hämmerling
Jul 1, 1986·The Journal of Clinical Investigation·A ToblerH P Koeffler
May 1, 1986·British Journal of Haematology·G J MuftiJ A Copplestone
May 1, 1986·American Journal of Hematology·M A BaumannR H Keller
Oct 1, 1983·Journal of Clinical Pathology·S MartinJ A Child
Mar 1, 1984·British Journal of Cancer·K TachibanaY Kishino
Apr 1, 1984·Journal of Clinical Psychopharmacology·T AyersC J Wallace
Apr 1, 1982·The Journal of Clinical Investigation·D Douer, H P Koeffler
Jul 1, 1993·Leukemia Research·G PrindullB Prindull
Aug 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R KurzrockM Talpaz

❮ Previous
Next ❯

Citations

Oct 1, 1996·Bone·L MellibovskyR R Recker
Sep 30, 1998·British Journal of Haematology·V Santini, P R Ferrini
May 7, 1998·Leukemia & Lymphoma·A Ganser, M Karthaus
Mar 1, 1996·Baillière's Clinical Haematology·M A BoogaertsH Demuynck
Nov 1, 1995·British Journal of Haematology·R CiottiA Pezzoli
Mar 1, 1996·Pediatric Hematology and Oncology·I IlhanM Büyükpamukçu
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Ekaterina GolovniaIgor O Fritsky
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Yurii S MorozMatti Haukka
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Nikolay M DudarenkoElżbieta Gumienna-Kontecka
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Valentina A KalibabchukElżbieta Gumienna-Kontecka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.