Changes in expression and activity levels of ecto-5'-nucleotidase/CD73 along the mouse female estrous cycle.

Acta Physiologica
E AliagasM Martín-Satué

Abstract

Extracellular ATP and its hydrolysis product adenosine modulate various reproductive functions such as those requiring contraction, hormone synthesis and maintenance of fluid composition. Moreover, adenosine is a key molecule for sperm capacitation. Extracellular nucleotide and nucleoside levels are affected by cell surface ectonucleotidases, amongst which the ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) family is the most abundant and effective to hydrolyse ATP and ADP to AMP. In the female reproductive tract three members of this family have been recently identified: NTPDase1, NTPDase2 and NTPDase3 (Histochem. Cell Biol.131, 2009, 615). The purpose of the present study was to characterize in this system the expression profile of ecto-5'-nucleotidase (CD73), the enzyme generating adenosine from AMP. Immunological techniques and in situ enzymatic assays were used to characterize the ecto-5'-nucleotidase expression in the mouse female reproductive tract along the four stages of the estrous cycle, that were determined by vaginal smear examination. Ecto-5'-nucleotidase was abundantly detected in the corpora lutea of the ovaries, as well as in several epithelia, such as that of oviducts, uterus and endometrial glands....Continue Reading

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Citations

May 12, 2010·Histochemistry and Cell Biology·Mireia Martín-SatuéJean Sévigny
Dec 12, 2012·Purinergic Signalling·Elisabet AliagasMireia Martín-Satué
Dec 14, 2011·Acta Physiologica·P B Persson
Nov 26, 2013·Purinergic Signalling·Geoffrey Burnstock
Dec 8, 2015·The Journal of Clinical Investigation·Jessica L BowserRussell R Broaddus
Oct 3, 2014·Mediators of Inflammation·Laura TexidóMireia Martín-Satué
Apr 8, 2014·Mediators of Inflammation·Elisabet AliagasMireia Martín-Satué
May 20, 2015·Autonomic Neuroscience : Basic & Clinical·George I Gorodeski
Jun 28, 2018·The Journal of Physiological Sciences : JPS·N KeatingL R Quinlan
Mar 14, 2019·Frontiers in Molecular Neuroscience·Gabriela Manzano NievesKevin G Bath

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