Changes in extracellular dopamine in the rat globus pallidus induced by typical and atypical antipsychotic drugs

Neurochemistry International
Holger Fuchs, Wolfgang Hauber

Abstract

Typical antipsychotic drugs with a high extrapyramidal motor side-effects liability markedly increase extracellular dopamine in the caudate-putamen, while atypical antipsychotic drugs with a low incidence of extrapyramidal motor side-effects have less pronounced stimulating actions on striatal dopamine. Therefore, it has been suggested that the extrapyramidal motor side-effects liability of antipsychotic drugs (APD) is correlated with their ability to increase extracellular dopamine in the caudate-putamen. The globus pallidus (GP) is another basal ganglia structure probably mediating extrapyramidal motor side-effects of typical antipsychotic drugs. Therefore, the present study sought to determine whether extracellular dopamine in the globus pallidus might be a further indicator to differentiate neurochemical actions of typical and atypical antipsychotic drugs. Using in vivo microdialysis we compared effects on pallidal dopamine induced by typical and atypical antipsychotic drugs in rats. Experiment I demonstrated that systemic administration of haloperidol (1 mg/kg; i.p.) and clozapine (20 mg/kg; i.p.) induced a significant pallidal dopamine release to about 160 and 180% of baseline, respectively. Experiment II revealed that re...Continue Reading

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Sep 26, 2003·Experimental Brain Research·Holger Fuchs, Wolfgang Hauber

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Citations

Sep 24, 2011·Neuroscience·M E RiceS J Cragg
Jan 15, 2010·Journal of Neurochemistry·Matthew James GirgentiSamuel Sathyanesan Newton
Sep 22, 2005·Journal of Neuroscience Research·Mikael AnderssonIngrid Strömberg
Nov 1, 2020·International Journal of Molecular Sciences·Marie A LabouesseTommaso Patriarchi

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