Changes in extracellular kynurenic acid concentrations in rat prefrontal cortex after D-kynurenine infusion: an in vivo microdialysis study.

Neurochemical Research
Tadahiro OgayaTakeshi Fukushima

Abstract

Using a microdialysis technique, we continuously infused D-kynurenine (KYN) (0, 50, and 100 microM) into the prefrontal cortices (PFCs) of male Sprague-Dawley rats. We then used column-switching high-performance liquid chromatography to assess the alterations in the concentration of kynurenic acid (KYNA)-an antagonist of N-methyl-D-aspartate and alpha7 nicotinic acetylcholine receptors-in the extracellular fluid in the PFC. Local infusion of D-KYN into the PFC remarkably increased the extracellular KYNA concentration, indicating that D-KYN is metabolized to KYNA in the PFC. The D-KYN-induced increase in KYNA levels was significantly attenuated by the co-administration of 3-methylpyrazole-5-carboxylic acid (AS057278)-a specific inhibitor of D-amino acid oxidase (DAAO). These results suggest that DAAO may be involved in the production of KYNA from D-KYN in the PFC in vivo.

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Citations

Jul 2, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Sumiko IwasaTakeshi Fukushima
Dec 15, 2015·Journal of Neurochemistry·Francesca M NotarangeloRobert Schwarcz
Apr 14, 2012·Brain Research·Xiao-Dan WangRobert Schwarcz
Jan 10, 2012·Journal of Neurochemistry·Veronica Pérez-de la CruzRobert Schwarcz
Oct 17, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Camilo RojasBarbara S Slusher
Feb 21, 2013·Neuropharmacology·Christian KleinAyikoe G Mensah-Nyagan
Feb 8, 2011·Neuropharmacology·Viviane LabrieJohn C Roder
Oct 26, 2013·Analytical and Bioanalytical Chemistry·Xiao-Dan WangRobert Schwarcz
Mar 11, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hideaki IizukaTakeshi Fukushima

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