Changes in food intake and forestomach motility of dwarf goats by recombinant bovine cytokines (IL-1 beta, IL-2) and IFN-gamma

Physiology & Behavior
A S van MiertC T van Duin

Abstract

The present study was carried out to investigate the effects of rboIL-1 beta, rboIL-2, and rboIFN-gamma on food intake and forestomach motility in conscious dwarf goats. The intravenous injection of rboIL-1 beta (1 micrograms kg-1) resulted in tachycardia and an immediate fever that reached peak values 45 and 180 min after injection. At 9 to 13 min after rboIL-1 beta administration, both frequency and amplitude of rumen contractions rapidly diminished, being minimal at 30 min; during the fever, all goats refused to eat. Compared with the fever induced by rboIL-1 beta, that caused by rboIFN-gamma (2 micrograms kg-1 IV) was delayed in onset. Although the biphasic fever after rboIFN-gamma was more pronounced than after rboIL-1 beta, the changes in forestomach motility, food intake, and heart rate were less than after rboIL-1 beta. No changes in rectal temperature, heart rate, forestomach motility, and food intake were observed after rboIL-2 (1 micrograms kg-1 IV) injection. These results strongly indicate that the effects of cytokines on body temperature can be dissociated from their effects on food intake. Furthermore, these data suggest a possible relationship between forestomach motility and food intake.

References

Dec 1, 1992·Journal of Veterinary Pharmacology and Therapeutics·A S van MiertT Wensing
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F LauriaS Tura
Oct 30, 1990·Neuroscience Letters·T IshikawaM Karibe
Mar 30, 1990·Biochemical and Biophysical Research Communications·T OkumuraM Namiki
Sep 1, 1990·The Journal of Physiology·N MurakamiT Watanabe
Dec 14, 1990·Biochemical and Biophysical Research Communications·A UeharaM Namiki
Jan 1, 1988·Reviews of Infectious Diseases·C A DinarelloS M Wolff
Nov 7, 1989·European Journal of Pharmacology·A UeharaM Namiki
Oct 1, 1987·The Journal of Physiology·A MorimotoT Watanabe
Jan 1, 1988·Physiology & Behavior·I G OtternessG O Daumy
Jun 1, 1986·The Journal of Experimental Medicine·C A DinarelloJ V O'Connor
Nov 1, 1969·European Journal of Pharmacology·F H Leenen, A S van Miert
Sep 1, 1984·The Journal of Clinical Investigation·C A DinarelloF Coceani
Aug 1, 1981·Physiology & Behavior·C A BaileC A Catanzaro

❮ Previous
Next ❯

Citations

Sep 1, 1996·Veterinary Immunology and Immunopathology·S P AlsemgeestE Gruys
Feb 1, 1996·Nutrition·C R Plata-Salamán
Jan 16, 1999·The Journal of Surgical Research·M VarmaH J Kim
Sep 3, 1998·European Journal of Clinical Investigation·F S Lehmann, G A Stalder
Mar 21, 1998·Journal of Veterinary Pharmacology and Therapeutics·A S van Miert, C T van Duin
Jun 6, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E Guerrero-LindnerM A Plaza
Jan 26, 1999·Annals of the New York Academy of Sciences·C R Plata-Salamán
Jul 30, 1999·The American Journal of Clinical Nutrition·S S Yeh, M W Schuster
Jun 9, 2021·Journal of Dairy Science·W E Brown, B J Bradford

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.