Changes in food intake and forestomach motility of dwarf goats by recombinant bovine cytokines (IL-1 beta, IL-2) and IFN-gamma

Physiology & Behavior
A S van MiertC T van Duin


The present study was carried out to investigate the effects of rboIL-1 beta, rboIL-2, and rboIFN-gamma on food intake and forestomach motility in conscious dwarf goats. The intravenous injection of rboIL-1 beta (1 micrograms kg-1) resulted in tachycardia and an immediate fever that reached peak values 45 and 180 min after injection. At 9 to 13 min after rboIL-1 beta administration, both frequency and amplitude of rumen contractions rapidly diminished, being minimal at 30 min; during the fever, all goats refused to eat. Compared with the fever induced by rboIL-1 beta, that caused by rboIFN-gamma (2 micrograms kg-1 IV) was delayed in onset. Although the biphasic fever after rboIFN-gamma was more pronounced than after rboIL-1 beta, the changes in forestomach motility, food intake, and heart rate were less than after rboIL-1 beta. No changes in rectal temperature, heart rate, forestomach motility, and food intake were observed after rboIL-2 (1 micrograms kg-1 IV) injection. These results strongly indicate that the effects of cytokines on body temperature can be dissociated from their effects on food intake. Furthermore, these data suggest a possible relationship between forestomach motility and food intake.


Dec 1, 1992·Journal of Veterinary Pharmacology and Therapeutics·A S van MiertT Wensing
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F LauriaS Tura
Oct 30, 1990·Neuroscience Letters·T IshikawaM Karibe
Mar 30, 1990·Biochemical and Biophysical Research Communications·T OkumuraM Namiki
Sep 1, 1990·The Journal of Physiology·N MurakamiT Watanabe
Dec 14, 1990·Biochemical and Biophysical Research Communications·A UeharaM Namiki
Jan 1, 1988·Reviews of Infectious Diseases·C A DinarelloS M Wolff
Nov 7, 1989·European Journal of Pharmacology·A UeharaM Namiki
Oct 1, 1987·The Journal of Physiology·A MorimotoT Watanabe
Jan 1, 1988·Physiology & Behavior·I G OtternessG O Daumy
Jun 1, 1986·The Journal of Experimental Medicine·C A DinarelloJ V O'Connor
Nov 1, 1969·European Journal of Pharmacology·F H Leenen, A S van Miert
Sep 1, 1984·The Journal of Clinical Investigation·C A DinarelloF Coceani
Aug 1, 1981·Physiology & Behavior·C A BaileC A Catanzaro

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