Changes in forced vital capacity over time in systemic sclerosis: application of group-based trajectory modelling

Rheumatology
Ada ManRobert W Simms

Abstract

An accelerated rate of decline in forced vital capacity (FVC) affects >50% of patients with SSc but data on the variability and determinants of this change are scarce. We sought to identify trajectories of FVC and their associated variables in SSc patients over a 12-year period. Clinical and pulmonary function data were retrospectively collected. SSc patients with three or more FVC values were included. Group-based modelling was used to cluster similar FVC patterns into trajectories. Baseline variables were associated with the trajectories using multinomial logistic regression. The effect of CYC on FVC was examined with each trajectory as a time-varying covariate. In 254 SSc patients we identified seven distinct FVC trajectories: very low slow decline (5.5%), very low improve (13.8%), low fast decline (9.5%), low stable (19.7%), low-normal improve (31.1%), normal improve (16.1%) and normal stable (4.3%). Younger age and the presence of pulmonary hypertension, Interstitial lung disease and shortness of breath at baseline significantly increased the odds of declining trajectories vs the reference trajectory (low-normal improve). CYC was associated with FVC improvement in the low fast decline trajectory. The course of FVC in SSc w...Continue Reading

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Citations

Aug 8, 2015·Arthritis & Rheumatology·Colin B Ligon, Fredrick M Wigley
Mar 15, 2016·Current Rheumatology Reports·Colin Ligon, Laura K Hummers
May 18, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Melissa CaronRussell Steele
Aug 16, 2019·Current Opinion in Rheumatology·Daniel J DeMizio, Elana J Bernstein
Nov 22, 2019·Modern Rheumatology·Masataka Kuwana, Arata Azuma
May 23, 2019·Multidisciplinary Respiratory Medicine·Nicola CiancioGianluca Sambataro
Jun 9, 2020·Expert Review of Clinical Immunology·Yoshioki Yamasaki, Masataka Kuwana
Jun 21, 2020·Arthritis & Rheumatology·Robert W Simms
Apr 25, 2018·The Journal of Dermatology·Yoshihide AsanoHironobu Ihn
Oct 1, 2019·Expert Review of Clinical Immunology·Oliver DistlerToby M Maher
Jan 8, 2020·Respiratory Research·Claudia ValenzuelaMichael Kreuter
Sep 30, 2020·Annals of the Rheumatic Diseases·Anna-Maria Hoffmann-VoldUNKNOWN EUSTAR collaborators
Jan 20, 2019·Respiratory Research·Vincent Cottin, Kevin K Brown
Mar 26, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Madelon C VonkYannick Allanore
Mar 21, 2021·Current Opinion in Rheumatology·David RoofehDinesh Khanna
Apr 4, 2021·Pharmaceuticals·Eun Ha Kang, Yeong Wook Song
Aug 12, 2021·Therapeutic Advances in Musculoskeletal Disease·Masataka KuwanaAlbert Selva-O'Callaghan
Sep 3, 2021·Therapeutic Advances in Musculoskeletal Disease·Panagiotis PanagopoulosAthanasios Tzioufas
Nov 3, 2021·Current Medical Research and Opinion·Ilaria GalettiCarla Garbagnati

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